10 min | Latest | RadOnc | Publication Source

• Podcast based on: Alerasool P, Zhou S, Miller E, Anker J, Tsao B, Kyprianou N, Tsao C-K. A Personalized Approach for Oligometastatic Prostate Cancer: Current Understanding and Future Directions. Cancers. 2025; 17(1):147. https://doi.org/10.3390/cancers17010147 Type: Review | Publication date: Jan 5, 2025
• Summary: This research review examines oligometastatic prostate cancer (OMPC), an intermediate stage between localised and widespread disease offering potential for cure. The article explores diagnostic challenges, focusing on PSMA PET scans, and reviews current treatment strategies, including metastasis-directed therapy (MDT) and combinations of systemic therapies with prostate cytoreduction. Ongoing clinical trials investigating MDT and various systemic therapies are highlighted, alongside the potential of artificial intelligence for personalised treatment. The authors emphasise the need for clearer OMPC definitions and the development of predictive biomarkers to optimise treatment selection and improve patient outcomes. Future directions focus on improving diagnostic accuracy, developing novel therapies, and leveraging artificial intelligence to refine treatment strategies.
• Keywords: prostate cancer; oligometastatic disease; oligometastasis; stereotactic body radiotherapy; focal therapy; androgen deprivation therapy; metastasis-directed therapy; castration-resistant prostate cancer; PSMA PET scan; radical prostatectomy

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