Forrmer academic Arthur Opp weighs 550 pounds and hasn’t left his rambling Brooklyn home in a decade. Twenty miles away in Yonkers, seventeen-year-old Kel Keller navigates life as the poor kid in a rich school and pins his hopes on what seems like a promising baseball career - if he can untangle himself from his family drama.

Ada Sibelius is raised by David, a single father and head of a computer science lab in Boston. Homeschooled, she accompanies her loving father - brilliant, eccentric, socially inept - to work every day. By 12 she is a painfully shy prodigy. At the same time that the lab begins to gain acclaim, David's mind begins to falter, and his mysterious past comes into question. When her father moves into a nursing home, Ada is taken in by one of David's colleagues. She embarks on a mission to uncover her father's secrets.

The Overstory unfolds in concentric rings of interlocking fable that range from antebellum New York to the late 20th-century Timber Wars of the Pacific Northwest and beyond. An air force loadmaster in the Vietnam War is shot out of the sky, then saved by falling into a banyan. An artist inherits 100 years of photographic portraits, all of the same doomed American chestnut. A hard-partying undergraduate in the late 1980s electrocutes herself, dies, and is sent back into life by creatures of air and light.

Traumatized by the bombing of Dresden at the time he had been imprisoned, Pilgrim drifts through all events and history, sometimes deeply implicated, sometimes a witness. He is surrounded by Vonnegut's usual large cast of continuing characters (notably here the hack science fiction writer Kilgore Trout and the alien Tralfamadorians, who oversee his life and remind him constantly that there is no causation, no order, no motive to existence).

Kit Darling is a maid with a snooping problem. She’s the “invisible girl,” compelled to poke into her wealthy clients’ closely guarded lives. It’s a harmless hobby until Kit sees something she can’t unsee in the home of her brand-new clients: a secret so dark it could destroy the privileged couple expecting their first child. This makes Kit dangerous to the couple. In turn, it makes the couple—who might kill to keep their secret—dangerous to Kit.