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137. Supporting Brain Health & Cognitive Function by Harnessing the Power of the Gut Microbiome | Focusing on Microbial Metabolites Including SCFAs & Indole-3-Propionate
- 2024/08/23
- 再生時間: 28 分
- ポッドキャスト
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サマリー
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あらすじ・解説
In today's episode, we dive into the crucial roles that gut-derived microbial metabolites, particularly short-chain fatty acids and tryptophan metabolites, play in supporting the health of neurons and glial cells, ultimately promoting cognitive function. We explore how enhancing the body’s natural production of these metabolites through a healthy gut microbiome and how strategic supplementation can both benefit brain health. The discussion includes detailed insights into the cellular mechanisms in the brain and practical strategies for fostering a healthy gut microbiome capable of producing high quantities of these beneficial compounds. Topics: 1. Introduction to Brain Cellular Makeup - Overview of Neurons and Glial Cells - Neurons: Structure and Function - Glial Cells: Types and Roles 2. Neuronal Communication and Synaptic Function - Neuronal Structure: Soma, Dendrites, Axon - Synaptic Communication: Presynaptic Terminal, Synaptic Cleft, Postsynaptic Membrane 3. Energy Demands - ATP Utilization and Energy Demands - Mitochondrial Function and Neuronal Vulnerability 4. Astrocytes and Microglial Cells - Astrocytes: Functions and Role in CNS Homeostasis - Microglial Cells: Immune Functions and Role in Neuroinflammation 5. Roles of Gut-Derived Microbial Metabolites in Supporting Brain Health - Overview of Gut-Derived Metabolites - Short-Chain Fatty Acids (SCFAs): Acetate, Propionate, Butyrate - Tryptophan Metabolites: Indole, Indole-3-Propionate (IPA) 6. Impact of Gut-Derived Metabolites on Neurons - Promotion of Neurogenesis by SCFAs - Neuroprotective Effects of Tryptophan Metabolites 7. Impact of Gut-Derived Metabolites on Glial Cells - Impact on Astrocytes - Impact on Microglial Cells 8. Strategies to Enhance Metabolite Production - Diversity - Probiotic Supplementation - Fiber - Amino Acids 9. Direct Supplementation Options - Sodium Butyrate: Role in Neuroprotection and Cognitive Function Thank you to our episode sponsors: 1. Check out Daily Nouri and use code CHLOE20 for 20% off your order. 2. Check out AX3 Astaxanthin and use discount code CHLOE20 for 20% off your first order. 3. Check out Liver Medic and use code Chloe20 to save 20% on "Leaky Gut Repair" Brendan's YouTube Channel https://x.com/livermedic Thanks for tuning in! Get Chloe's Book Today! "75 Gut-Healing Strategies & Biohacks" Follow Chloe on Instagram @synthesisofwellness Follow Chloe on TikTok @chloe_c_porter Visit synthesisofwellness.com to purchase products, subscribe to our mailing list, and more! --- Support this podcast: https://podcasters.spotify.com/pod/show/chloe-porter6/support