Co-hosts Anne Chappelle and David Faulkner speak with William J. Sullivan, PhD, Showalter Professor of Pharmacology & Toxicology and Professor of Microbiology & Immunology with the Indiana University School of Medicine, about toxic parasites lying dormant in your brain and the power and importance of science communication.

About the Guest
Bill Sullivan, PhD, has been studying the intracellular parasite Toxoplasma gondii since he was a graduate student in the laboratory of Dr. David Roos at the University of Pennsylvania in 1994. He completed postdoctoral fellowships with Dr. Chuck Smith at ELANCO (a division of Eli Lilly, Co.) and Dr. Sherry Queener at the Indiana University School of Medicine. He became an Assistant Professor at the Indiana University School of Medicine in 2003. Dr. Sullivan is now the Showalter Professor of Pharmacology & Toxicology and Microbiology & Immunology at the Indiana University School of Medicine.

Dr. Sullivan’s lab studies cellular signaling and the regulation of gene expression in a fascinating protozoan parasite called Toxoplasma gondii. Toxoplasma causes congenital birth defects as well as opportunistic infection in HIV/AIDS, cancer chemotherapy, and heart transplant patients. There is also emerging evidence that this parasitic infection may be linked to neurological disorders, such as schizophrenia and behavior modification. While the acute stage of toxoplasmosis can be treated, the ability of the parasite to convert into latent tissue cysts prevents eradication of the infection from the patient. Unfortunately, if immunity wanes, the patient can relapse and suffer additional episodes of life-threatening acute infection. Additionally, toxoplasma is a serious threat to some wildlife and livestock.

Send SOT thoughts on the episodes, ideas for future topics, and more.

As the foremost experts on the effects of chemicals, biological substances, and more, toxicologists are key contributors to health regulation and laws. Law Professor and lawyer Claudia Polsky, University of California Berkeley, discusses how science can influence environmental health law, as well as environmental justice, with co-hosts Anne Chappelle and David Faulkner and reveals legal gaps in protecting public health.

About the Guest
Claudia Polsky, JD, MAS, is a Clinical Professor of Law and the founding Director of the Environmental Law Clinic.

Before launching the Clinic, Ms. Polsky spent 18 years as a public sector and public interest environmental litigator: 14 as a Deputy Attorney General in the Environment Section of the California Department of Justice and four at Earthjustice and Public Citizen Litigation Group. She has litigated cases in trial and appellate courts, including the US Supreme Court; testified before Congress and the California legislature; and drafted and successfully defended environmental regulations.

Ms. Polsky also served as Deputy Director for Pollution Prevention and Green Technology at California’s Department of Toxic Substances Control. There, she managed a program that addressed an area of ongoing professional focus: reducing exposure to toxic chemicals throughout the supply chain, from workers to consumers and communities impacted by toxic waste. The Environmental Law Clinic handles many toxics-reduction matters, ranging from pesticide exposure cases to the regulation of hazardous ingredients in consumer products. It also addresses other issues of environmental health and environmental justice, including climate justice and access to safe drinking water for all.

Ms. Polsky’s past environmental advocacy work has encompassed negotiating conservation easements for The Nature Conservancy; protecting threatened Pacific salmon populations through dam removal; obtaining an injunction to save 50 million national forest acres from logging and roadbuilding; and serving as a volunteer park ranger in Yosemite, Grand Canyon, and Great Smoky Mountains National Parks.

Send SOT thoughts on the episodes, ideas for future topics, and more.

While pharmaceuticals provide positive benefits for patients, what about workers that may be exposed during production? Elizabeth M. Vancza, Merck & Co. Inc., reveals to co-hosts Anne Chappelle and David Faulkner the role of occupational toxicologists in understanding the exposure risks of pharmaceuticals, chemicals, and other substances that may affect worker health, as well as how to protect them from these exposures.

About the Guest
Elizabeth M. Vancza, PhD, DABT, is currently an Associate Director of Occupational Toxicology at Merck & Co. Inc., where she assists business operations in the areas of occupational toxicology, potent compound safety evaluation and awareness, product quality/safety, and hazard/risk assessment. Before joining Merck in 2021, she worked as an occupational toxicologist for SafeBridge Consultants for over 10 years, serving clients worldwide, primarily from the pharmaceutical and biotechnology industries.

Dr. Vancza earned her PhD and MS degrees from New York University, with respective concentrations in inhalation toxicology and immunotoxicology, and she remains a guest lecturer for the graduate program in the areas of risk assessment and genomics. She also is an Associate Member of the Occupational Alliance for Risk Science (OARS) Workplace Environmental Exposure Level (WEEL) Committee.

Dr. Vancza joined the Society of Toxicology (SOT) in 2004 and has remained an active member through her involvement on various committees and student outreach efforts for several Specialty Sections, Regional Chapters, and Special Interest Groups. She most recently completed a three-year term as Vice President (year one), President (year two), and Past President (year three) for the SOT Northeast Regional Chapter in 2021.

Send SOT thoughts on the episodes, ideas for future topics, and more.