In this episode of Advancements in Oncology features a discussion on the latest developments in colorectal cancer research, focusing on the importance of molecular sub typing and personalised treatment strategies. Dr. Anguraj Sadanandam and Dr. Bjorn Ghillemijn explore the challenges faced in clinical practice, the potential of integrating molecular classifications into routine diagnostics, and the role of immunotherapy in treating colorectal cancer. They emphasise the need for actionable tools to improve patient outcomes and the future directions of research in this field.Highlights- Colorectal cancer treatment is evolving with molecular subtyping.- Personalized treatment decisions are still heavily reliant on traditional methods.- Molecular subtyping can enhance treatment predictions and responses.- There is an urgent need for actionable tests in clinical practice.- Immunotherapy shows promise but requires more data for broader application.- Inflammatory signatures may play a role in immunotherapy effectiveness.- Multi-omics data presents new opportunities for understanding cancer.- The integration of AI in cancer research is becoming essential.- Current treatment options are often based on outdated criteria.- Future research should focus on granular patient classification.

Chapters

00:00 Introduction to Colorectal Cancer Research

01:03 Personal Journey in Colorectal Cancer Oncology

02:34 Challenges in Personalised Treatment Decisions

06:23 The Role of Molecular Subtyping

10:08 Integrating Molecular Subtyping into Clinical Practice

12:01 Immunotherapy and Inflammatory Signatures

16:32 Future Directions in Molecular Research

18:44 Concluding Thoughts on Treatment Advancements