Theodore Schwartz stands at the pinnacle of neurosurgical expertise. With over 500 published articles, 200 pieces of commentary, and 5 patents to his name—effectively producing a scholarly work every two weeks for three decades—Schwartz has spent most of his career at Weill Cornell Medicine, where he pioneered new minimally-invasive surgical techniques and led the Epilepsy Research Laboratory, among many (many) other things. His recent book Gray Matters: A Biography of Brain Surgery offers readers an insider's view of one of medicine's most demanding specialties.

Tyler and Ted discuss how the training for a neurosurgeon could be shortened, the institutional factors preventing AI from helping more in neurosurgery, how to pick a good neurosurgeon, the physical and mental demands of the job, why so few women are currently in the field, whether the brain presents the ultimate bottleneck to radical life extension, why he thinks free will is an illusion, the success of deep brain stimulation as a treatment for neurological conditions, the promise of brain-computer interfaces, what studying epilepsy taught him about human behavior, the biggest bottleneck limiting progress in brain surgery, why he thinks Lee Harvey Oswald acted alone, the Ted Schwartz production function, the new company he’s starting, and much more.

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Recorded January 31st, 2025.

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Few understand both the promise and limitations of artificial general intelligence better than Jack Clark, co-founder of Anthropic. With a background in journalism and the humanities that sets him apart in Silicon Valley, Clark offers a refreshingly sober assessment of AI's economic impact—predicting growth of 3-5% rather than the 20-30% touted by techno-optimists—based on his firsthand experience of repeatedly underestimating AI progress while still recognizing the physical world's resistance to digital transformation.

In this conversation, Jack and Tyler explore which parts of the economy AGI will affect last, where AI will encounter the strongest legal obstacles, the prospect of AI teddy bears, what AI means for the economics of journalism, how competitive the LLM sector will become, why he’s relatively bearish on AI-fueled economic growth, how AI will change American cities, what we'll do with abundant compute, how the law should handle autonomous AI agents, whether we’re entering the age of manager nerds, AI consciousness, when we'll be able to speak directly to dolphins, AI and national sovereignty, how the UK and Singapore might position themselves as AI hubs, what Clark hopes to learn next, and much more.

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Recorded March 28th, 2025.

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Harvard economist Kenneth Rogoff approaches global finance with the same strategic foresight that made him a chess grandmaster. Author of the new book Our Dollar, Your Problem, Rogoff doesn't sugarcoat America's future: he foresees a significant inflation shock within a decade, far more severe than the post-COVID bout. When this second wave hits, he warns, "credibility's really going to be shot."

In this conversation, Ken and Tyler tackle international economic dynamics, unresolved macro puzzles, the state of chess, and more, including whether trade deficits are truly unsustainable, why China's investment-heavy growth model has reached its limits, how currency depreciation neutralizes tariff effects, Pakistan’s IMF bailouts, whether more Latin American countries should dollarize, Japan's deceptively peaceful economic decline, Europe's coming fiscal reckoning, how the US will eventually confront its ballooning debt, the puzzling absence of a recession during our recent disinflation, the potential of phasing out large denomination currency notes, the future relevance of stablecoins, whether America should start a CBDC, Argentina's chances under Milei, who will be the next dominant player in chess, hanging out with Bobby Fischer, drawing out against Magnus Carlsen, and how to save classical chess from excessive computer preparation.

Read a full transcript enhanced with helpful links, or watch the full video.

Recorded April 2nd, 2025.

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