19 min | Latest | RadOnc | Publication Source

• Podcast based on: Geirnaert F, Kerkhove L, Montay-Gruel P, Gevaert T, Dufait I, De Ridder M. Exploring the Metabolic Impact of FLASH Radiotherapy. Cancers. 2025; 17(1):133. https://doi.org/10.3390/cancers17010133 Type: Review | Publication date: Jan 3, 2025
• Summary: This review article examines the metabolic effects of flash radiotherapy (flash RT), a novel cancer treatment delivering radiation at ultra-high dose rates. The authors explore how flash RT impacts cellular metabolism differently in healthy versus cancerous tissues, focusing on reactive oxygen species (ROS), iron metabolism, lipid peroxidation, and mitochondrial function. Key findings suggest flash RT reduces ROS-induced damage in healthy tissue by preserving mitochondrial integrity and attenuating lipid peroxidation, while still effectively targeting tumours. The review highlights the need for further research using more complex biological systems to fully understand and optimise flash RT's clinical potential.
• Keywords: FLASH radiotherapy; FLASH effect; ultrahigh dose rate radiotherapy; metabolism; reactive oxygen species; mitochondria; lipid peroxidation

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