Episode 19 of the Performance Around the Clock podcast comes from the 2024 Society for Research on Biological Rhythms (SRBR) biennial meeting in San Juan, Puerto Rico. We have the honor to talk with one of the pillars of the circadian field - Dr. Joseph Takahashi. Dr. Takahashi pioneered the use of forward genetics and positional cloning in mouse as a tool to discover genes that underlie neurobiology and behavior. His discovery of clock genes led to a description of a conserved circadian clock mechanism in animals. In this podcast, we hear about how his lab discovered and cloned the mouse circadian Clock gene. In addition, we find out how circadian alignment of feeding, daily fasting and caloric restriction can combine to increase longevity.

Dr. Takahashi has authored more than 300+ scientific publications and the recipient of many awards and distinctions including:

The Honma Prize in Biological Rhythms Research

NSF Presidential Young Investigator Award

Searle Scholars Award

Bristol-Myers Squibb Unrestricted Grant in Neuroscience, and the C. U. Ariens Kappers Medal. W. Alden Spencer Award in Neuroscience from Columbia University

Fellow of the American Academy of Arts and Sciences

Member of the National Academy of Sciences

Member of the National Academy of Medicine

Gruber Neuroscience Prize at the Society for Neuroscience

Guest:

Dr. Joseph Takahashi

Chair of the Department of Neuroscience at UT Southwestern Medical Center

Loyd B. Sands Distinguished Chair in Neuroscience

X (formerly Twitter): @CircadianClocks

https://twitter.com/circadianclocks

UT Southwestern profile:

https://profiles.utsouthwestern.edu/profile/105885/joseph-takahashi.html

Lab webpage:

https://labs.utsouthwestern.edu/takahashi-lab

Host:

Dr. Satchin Panda

@SatchinPanda

https://x.com/SatchinPanda

Instagram: @satchin.panda

https://www.instagram.com/satchin.panda/

Links:

Donations: https://panda.salk.edu/giving/

Research: https://www.salk.edu/scientist/satchidananda-panda/

More science: https://mycircadianclock.org/