Join Drs Tania Jain and Raajit Rampal as they discuss TP53, post-MPN AML, and high-risk MPNs in the context of myelofibrosis.

Relevant disclosures can be found with the episode show notes on Medscape https://www.medscape.com/viewarticle/999596. The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.

Resources

Primary Myelofibrosis https://emedicine.medscape.com/article/197954-overview

Myeloproliferative Neoplasms https://www.ncbi.nlm.nih.gov/books/NBK531464/

Acute Myeloid Leukemia Following Myeloproliferative Neoplasms: A Review of What We Know, What We Do Not Know, and Emerging Treatment Strategies https://pubmed.ncbi.nlm.nih.gov/36632576/

Updated Safety and Efficacy Data From the Phase 3 MANIFEST-2 Study of Pelabresib in Combination With Ruxolitinib for JAK Inhibitor Treatment-Naïve Patients With Myelofibrosis https://meetings.asco.org/abstracts-presentations/231688

Next Generation Sequencing in MPNs. Lessons From the Past and Prospects for Use as Predictors of Prognosis and Treatment Responses https://pubmed.ncbi.nlm.nih.gov/32781570/

The MDM2 Antagonist Idasanutlin in Patients With Polycythemia Vera: Results From a Single-Arm Phase 2 Study https://ashpublications.org/bloodadvances/article/6/4/1162/483223/The-MDM2-antagonist-idasanutlin-in-patients-with

Venetoclax With Azacitidine or Decitabine in Blast-Phase Myeloproliferative Neoplasm: A Multicenter Series of 32 Consecutive Cases https://pubmed.ncbi.nlm.nih.gov/33844862/

Association of Factors Influencing Selection of Upfront Hematopoietic Cell Transplantation Versus Nontransplantation Therapies in Myelofibrosis https://pubmed.ncbi.nlm.nih.gov/33798769/

Genomic Analysis of Primary and Secondary Myelofibrosis Redefines the Prognostic Impact of ASXL1 Mutations: a FIM Study https://pubmed.ncbi.nlm.nih.gov/33666653/

TP53 and Decitabine in Acute Myeloid Leukemia and Myelodysplastic Syndromes https://pubmed.ncbi.nlm.nih.gov/27959731/

Safety and Efficacy of Combined Ruxolitinib and Decitabine in Accelerated and Blast-phase Myeloproliferative Neoplasms https://pubmed.ncbi.nlm.nih.gov/30563881/

Efficacy and Safety of Combination Therapies vs Monotherapy of Hypomethylating Agents in Accelerated or Blast Phase of Philadelphia Negative Myeloproliferative Neoplasms: a Systematic Review and Meta-analysis https://pubmed.ncbi.nlm.nih.gov/36644935/

Genomic and Functional Analysis of Leukemic Transformation of Myeloproliferative Neoplasms https://pubmed.ncbi.nlm.nih.gov/25516983/

BMP2/SMAD Pathway Activation in JAK2/p53-Mutant Megakaryocyte/Erythroid Progenitors Promotes Leukemic Transformation https://pubmed.ncbi.nlm.nih.gov/35421216/

Single-Cell Multi-omics Identifies Chronic Inflammation as a Driver of TP53-Mutant Leukemic Evolution https://pubmed.ncbi.nlm.nih.gov/37666991/

Join Drs Tania Jain and Lindsay Rein as they discuss the current treatment landscape and their approach to treating patients with myelofibrosis.

Relevant disclosures can be found with the episode show notes on Medscape https://www.medscape.com/viewarticle/999595. The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.

Resources

Primary Myelofibrosis https://emedicine.medscape.com/article/197954-overview

Myeloproliferative Neoplasms https://www.ncbi.nlm.nih.gov/books/NBK531464/

Acute Myeloid Leukemia (AML) Treatment Protocols https://emedicine.medscape.com/article/2004793-overview

Combined Ruxolitinib and Enasidenib in Patients With Accelerated/Blast-phase Myeloproliferative Neoplasm or Chronic-Phase Myelofibrosis With an IDH2 Mutation https://clinicaltrials.gov/study/NCT04281498

Momelotinib Versus Danazol in Symptomatic Patients With Anaemia and Myelofibrosis (MOMENTUM): Results From an International, Double-Blind, Randomised, Controlled, Phase 3 Study https://pubmed.ncbi.nlm.nih.gov/36709073/

Pacritinib Is a Potent ACVR1 Inhibitor With Significant Anemia Benefit in Patients With Myelofibrosis https://pubmed.ncbi.nlm.nih.gov/37552106/

Safety and Efficacy of Luspatercept for the Treatment of Anemia in Patients With Myelofibrosis https://pubmed.ncbi.nlm.nih.gov/38820422/

Venetoclax With Azacitidine or Decitabine in Blast-Phase Myeloproliferative Neoplasm: A Multicenter Series of 32 Consecutive Cases https://pubmed.ncbi.nlm.nih.gov/33844862/

Interferon Therapy in Myelofibrosis: Systematic Review and Meta-Analysis https://pubmed.ncbi.nlm.nih.gov/32669244/

Join Drs Tania Jain and Aaron Gerds as they discuss the latest developments in clinical trials and investigational therapeutics for MPNs.

Relevant disclosures can be found with the episode show notes on Medscape https://www.medscape.com/viewarticle/999594. The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.

Resources

Primary Myelofibrosis https://emedicine.medscape.com/article/197954-overview

Myeloproliferative Neoplasms https://www.ncbi.nlm.nih.gov/books/NBK531464/

Bromodomain and Extraterminal (BET) Proteins: Biological Functions, Diseases, and Targeted Therapy https://pubmed.ncbi.nlm.nih.gov/37926722/

Long-Term Survival in Patients Treated With Ruxolitinib for Myelofibrosis: COMFORT-I and -II Pooled Analyses https://pubmed.ncbi.nlm.nih.gov/28962635/

Rampal RK, Grosicki S, Chraniuk S, et al. Pelabresib in combination with ruxolitinib for Janus kinase inhibitor treatment-naïve patients with myelofibrosis: results of the MANIFEST-2 randomized, double-blind, phase 3 study. Program and abstracts of the 65th American Society of Hematology Annual Meeting and Exposition; December 10, 2023; San Diego, California. Abstract 628. https://ash.confex.com/ash/2023/webprogram/Paper179141.html

Pemmaraju N, Mead AJ, Somervaille T CP, et al.Transform-1: A randomized, double-blind, placebo-controlled, multicenter, international phase 3 study of navitoclax in combination with ruxolitinib versus ruxolitinib plus placebo in patients with untreated myelofibrosis. Program and abstracts of the 65th American Society of Hematology Annual Meeting and Exposition; December 10, 2023; San Diego, California. Abstract 620. https://ash.confex.com/ash/2023/webprogram/Paper173509.html

Defining Disease Modification in Myelofibrosis in the Era of Targeted Therapy https://pubmed.ncbi.nlm.nih.gov/35499819/

A Prognostic Model to Predict Survival After 6 Months of Ruxolitinib in Patients With Myelofibrosis https://pubmed.ncbi.nlm.nih.gov/35130339/

Imetelstat in Patients With Lower-Risk Myelodysplastic Syndromes Who Have Relapsed or Are Refractory to Erythropoiesis-Stimulating Agents (IMerge): A Multinational, Randomised, Double-Blind, Placebo-Controlled, Phase 3 Trial https://pubmed.ncbi.nlm.nih.gov/38048786/