Drs Todd A. Florin and Lilliam Ambroggio discuss biomarkers in pediatric pneumonia, their potential to determine etiology and predict disease course, target therapy, and determine response to therapy.

Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/987064). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.

Resources

Community-acquired Pneumonia in Children https://pubmed.ncbi.nlm.nih.gov/29932038/

RSV Through the COVID-19 Pandemic: Burden, Shifting Epidemiology, and Implications for the Future https://pubmed.ncbi.nlm.nih.gov/36811330/

Procalcitonin Use: Variation Across Hospitals and Trends Over Time https://pubmed.ncbi.nlm.nih.gov/34964049/

The Management of Community-acquired Pneumonia in Infants and Children Older Than 3 Months of Age: Clinical Practice Guidelines by the Pediatric Infectious Diseases Society and the Infectious Diseases Society of America https://pubmed.ncbi.nlm.nih.gov/21880587/

A Three-step Diagnosis of Pediatric Pneumonia at the Emergency Department Using Clinical Predictors, C-reactive Protein, and Pneumococcal PCR https://pubmed.ncbi.nlm.nih.gov/28474099/

A Prediction Model for Pediatric Radiographic Pneumonia https://pubmed.ncbi.nlm.nih.gov/34845493/

Biomarkers and Disease Severity in Children With Community-acquired Pneumonia https://pubmed.ncbi.nlm.nih.gov/32404432/

Procalcitonin Accurately Identifies Hospitalized Children With Low Risk of Bacterial Community-acquired Pneumonia https://pubmed.ncbi.nlm.nih.gov/28158460/

Improved Diagnostics Help to Identify Clinical Features and Biomarkers That Predict Mycoplasma Pneumoniae Community-acquired Pneumonia in Children https://pubmed.ncbi.nlm.nih.gov/31665253/

Procalcitonin-guided Use of Antibiotics for Lower Respiratory Tract Infection https://pubmed.ncbi.nlm.nih.gov/29781385/

Procalcitonin Guidance to Reduce Antibiotic Treatment of Lower Respiratory Tract Infection in Children and Adolescents (ProPAED): A Randomized Controlled Trial https://pubmed.ncbi.nlm.nih.gov/23936304/

Drs Todd A. Florin and Debra Palazzi discuss complicated pediatric pneumonia: what it is, how to diagnose it, and how to manage it.

Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/987063). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.

Resources

SHARPS Collaborative https://sharps.wustl.edu/

Management of Parapneumonic Effusions https://pubmed.ncbi.nlm.nih.gov/9646988

Streptococcus Pneumoniae: Virulence Factors and Variation https://pubmed.ncbi.nlm.nih.gov/20132250/

Light's Criteria https://reference.medscape.com/calculator/571/light-s-criteria

Accuracy of Lung Ultrasonography in the Diagnosis of Pneumonia in Adults: Systematic Review and Meta-Analysis https://pubmed.ncbi.nlm.nih.gov/27818332/

The Image Gently Alliance http://www.imagegently.org/

Ceftaroline Fosamil for the Treatment of Community-Acquired Pneumonia: From FOCUS to CAPTURE https://pubmed.ncbi.nlm.nih.gov/25193094/

The Pigtail Catheter for Pleural Drainage: A Less Invasive Alternative to Tube Thoracostomy https://pubmed.ncbi.nlm.nih.gov/10323171/

Drs Todd A. Florin and Derek J. Williams discuss the latest treatment strategies for pediatric pneumonia and challenge the long-standing method of treating pneumonia in children with mild disease.

Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/987061). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.

Resources

Potential Impact of Conjugate Pneumococcal Vaccines on Pediatric Pneumococcal Diseases https://pubmed.ncbi.nlm.nih.gov/15033641/

Forty Years of Molecular Diagnostics for Infectious Diseases https://pubmed.ncbi.nlm.nih.gov/35852340/

Community-Acquired Pneumonia Requiring Hospitalization Among U.S. Children https://pubmed.ncbi.nlm.nih.gov/25714161/

Causes of Severe Pneumonia Requiring Hospital Admission in Children Without HIV Infection From Africa and Asia: The PERCH Multi-Country Case-Control Study https://pubmed.ncbi.nlm.nih.gov/31257127/

Detection of Streptococcus pneumoniae in Whole Blood by PCR https://pubmed.ncbi.nlm.nih.gov/7751363/

Mycoplasma pneumoniae Infections: Pathogenesis and Vaccine Development https://pubmed.ncbi.nlm.nih.gov/33503845/

The Management of Community-Acquired Pneumonia in Infants and Children Older Than 3 Months of Age: Clinical Practice Guidelines by the Pediatric Infectious Diseases Society and the Infectious Diseases Society of America https://pubmed.ncbi.nlm.nih.gov/21880587/

Effect of Amoxicillin Dose and Treatment Duration on the Need for Antibiotic Re-treatment in Children With Community-Acquired Pneumonia: The CAP-IT Randomized Clinical Trial https://pubmed.ncbi.nlm.nih.gov/34726708/

Short-Course Antimicrobial Therapy for Pediatric Community-Acquired Pneumonia: The SAFER Randomized Clinical Trial https://pubmed.ncbi.nlm.nih.gov/33683325/

Short- vs Standard-Course Outpatient Antibiotic Therapy for Community-Acquired Pneumonia in Children: The SCOUT-CAP Randomized Clinical Trial https://pubmed.ncbi.nlm.nih.gov/35040920/