Join Drs Amelia Langston and Jean Koff as they discuss the monitoring and management of complications before, during, and after CAR T therapy.

Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/987066). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.

Resources

Cancer Immunotherapy With Chimeric Antigen Receptor (CAR) T Cells https://emedicine.medscape.com/article/2500108-overview

Cytokine Release Syndrome https://emedicine.medscape.com/article/2500111-overview

Immune Effector Cell Associated Neurotoxicity Syndrome in Chimeric Antigen Receptor-T Cell Therapy https://pubmed.ncbi.nlm.nih.gov/36081506/

On-target and Off-target-based Toxicologic Effects https://pubmed.ncbi.nlm.nih.gov/23085982/

Cytokine https://www.cancer.gov/publications/dictionaries/cancer-terms/def/cytokine

Tocilizumab (Rx) https://reference.medscape.com/drug/actemra-tocilizumab-999419

CARTOX 10 Point Neurological Assessment https://reference.medscape.com/viewarticle/886616_5

Levetiracetam https://www.ncbi.nlm.nih.gov/books/NBK499890/

Cytopenia After CAR-T Cell Therapy-A Brief Review of a Complex Problem https://pubmed.ncbi.nlm.nih.gov/35326654/

Immune Effector Cell-associated Hemophagocytic Lymphohistiocytosis-like Syndrome https://pubmed.ncbi.nlm.nih.gov/36906275/

Management of Hypogammaglobulinaemia and B-cell Aplasia https://www.ncbi.nlm.nih.gov/books/NBK584138/

Rituximab (Rx) https://reference.medscape.com/drug/rituxan-truxima-rituximab-342243

Bispecific Targeting of CD20 and CD19 Increases Polyfunctionality of Chimeric Antigen Receptor T-cell Products in B-cell Malignancies https://pubmed.ncbi.nlm.nih.gov/35597752/

Mantle Cell Lymphoma https://www.ncbi.nlm.nih.gov/books/NBK536985/

Chimeric Antigen Receptor (CAR) T-cell Treatment for Mantle Cell Lymphoma (MCL) https://pubmed.ncbi.nlm.nih.gov/35237395/

Apheresis https://www.cancer.gov/publications/dictionaries/cancer-terms/def/apheresis