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Researchers Identify a NEW Promising Model for Studying Human Aging #31
- 2023/09/09
- 再生時間： 9 分
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I hope you enjoy my content and find it interesting or informative, if so, please consider supporting the channel by using one of the affiliate links below: * Buy me a Kofi: https://ko-fi.com/mynmnexperiment * Patreon: https://bit.ly/3hhfjl5 * SubscribeStar: https://bit.ly/3psYo23Renue by Science 10% Discount Code: MYNMN (https://renuebyscience.com/?rfsn=5692699.331801&coupon-code=MYNMN) Renue by Science 15% Subscription Service Discount Code: MYNMNSUB Youth & Earth 15% Discount Code: MYNMN (https://youthandearth.com?sca_ref=3766764.knrWl4O3cB) ProHealth 15% Discount Code: MYNMN (https://www.prohealth.com/) DoNotAge 10% Discount Code: MYNMN (https://bit.ly/2VBDgNt)Please note that the links above are affiliate links, which means that if you use the code, I will receive a small commission, and if you do, may I say many thanks I advance for your support. My Current Anti-Aging Protocol:· 1.5 grams of NMN (https://bit.ly/3c2Fxt8) · 1.5 grams of Trans-resveratrol (Tue, Thu & Sat) (https://bit.ly/3yxeqy2) · 500mg Metformin· 1.5 grams of TMG (https://bit.ly/3oe1Ted) · 5,000 IU (International Units) of vitamin D3 (https://bit.ly/3P32hYH) · 120 mcg (micrograms) of vitamin K2 (Mk 7) (https://bit.ly/3PhkBgn) · 250mg Magnesium (L-Threonate) (https://bit.ly/3O4pZ5o) · 200mg high molecular weight hyaluronic acid (https://bit.ly/3P0Z4c2) · 2,400mg of Fisetin, on the 1st, 2nd & 3rd of each month (https://bit.ly/3P2rSB0) · 2,400mg of Quercetin, on the 1st, 2nd & 3rd of each month (https://bit.ly/3IzulAy)· Quercetin & Fisetin Periodic Dosing (https://bit.ly/3mw1IgN)· 81mg of aspirin (https://bit.ly/3uFjtem) · 800mg SIRT6 Activator (https://bit.ly/3MyfA4J)· 600mg DIM (https://bit.ly/3ZX9NsG)· 800mg GlyNAC (https://shorturl.ac/7b75r) For adults in their 40s, sarcopenia is hardly noticeable—about 3% muscle mass is lost each decade. However, for those aged 65 years and older, muscle decline can become much more rapid, with an average loss of 1% muscle mass per year.More importantly, sarcopenia is also marked by a decrease in strength, impaired gait, reduced physical activity and difficulty completing simple everyday tasks such walking, sitting down and standing up unaided. The Future The proportion of older adults aged 65+ is projected to more than double by the year 2060, this is driving research into the process of musculoskeletal decline.Researchers at Colorado State University's Columbine Health Systems Center for Healthy Aging believe they have found an animal model that will help them better understand it and find ways to limit the symptoms.The study, published in Frontiers in Physiology: Striated Muscle in October, is an example of using comparative medicine to understand human diseases and conditions. Animal ModelsScientists often rely on animal models to mimic disease progression and study the prevention, diagnosis and treatment of medical conditions.However, until now, no animal model has been able to fully capture all aspects of human musculoskeletal aging.Karyn Hamilton Karyn Hamilton, a professor in the Colorado State University's Department of Health and Exercise Science, and associate director at the Center for Healthy Aging said "Existing pre-clinical models either rely on unloading the muscle, meaning mimicking bedrest in an animal, or they must wait until the animals get really, really old, and even then they don't really get the same muscle aging phenotype as people do."Dunkin Hartley Guinea PigIn their work, Hamiliton's team found that the Dunkin Hartley guinea pig was a good candidate for a muscle aging model due to the animal's tendency to develop osteoarthritis at a young age.The two conditions, osteoarthritis and sarcopenia, seem to be linked in humans; with advancing age, skeletal muscle dysfunction increases the risk for osteoarthritis, and osteoarthritis increases the risk for further muscle decline.Hamilton’s teamHamilton teamed up with Dr. Kelly Santangelo—an associate professor in the Department of Microbiology, Immunology, and Pathology at CSU, who has been studying primary osteoarthritis in Hartley guinea pigs for many years, also Associate Professor Raoul Reiser, also in Department of Health and Exercise Science, to understand how skeletal muscle changes as osteoarthritis progresses in guinea pigs.The team hypothesized that those muscle changes may mimic human musculoskeletal aging. Classic signsMuscle composition also changes with age: fast-twitch fibers, which are larger and capable of exerting stronger forces, decrease in number, and slow-twitch fibers, which are smaller and less metabolically efficient, tend to increase.Generally, when people "lose muscle mass," it's the large, fast-twitch fibers that are affected, also with decreasing muscle mass tends to come an ...