In this episode, podcast host David Pechter invites SLAS Technology featured author Dr. Hossam Ibrahim (University College Dublin) to discuss his research on the dissemination of tumor cells to understand the mechanisms behind cancer metastasis. Tune in to hear how the research team developed a migration assay combining 3D models and a physiologically relevant extracellular matrix. Hear about the unique challenges faced by researchers while orchestrating the application of 3D technologies with high throughput screening methods.

For more, read Dr. Ibrahim's paper "A Biomimetic High Throughput Model of Cancer Cell Spheroid Dissemination onto Aligned Fibrillar Collagen". Dr. Ibrahim is a researcher at University College Dublin (UCD) in the School of Physics and also at the Nanoscale Function Group located in the Conway Institute of Biomolecular and Biomedical Research.

For more information about the journal, visit SLAS Technology or contact the SLAS publishing office at publishing@slas.org. 

Behind the Special Issue: Join podcast host David Pechter as he invites Joseph de Rutte (Partillion Bioscience) to discuss the paper: “Sorting single-cell microcarriers using commercial flow cytometers”. This research was featured in the recent SLAS Technology special issue, Single Cell Analysis Technologies. Listen in as they discuss the unique formation of microscopic, bowl-shaped containers they call nanovials, and the applications of these cell carriers in flow cytometry for functional single-cell assays. 

Dr. Joe de Rutte received his B.S. and M.S. in Mechanical Engineering from the University of California, Santa Barbara in 2014 and 2016 and received a Ph.D. in Bioengineering from the University of California, Los Angeles in 2020. He co-founded Partillion Bioscience in 2020 based on his Ph.D. research and currently leads the company as President. Dr. de Rutte was awarded the 2020 Society of Laboratory Automation and Screening Innovation Award in recognition of the impact of his “Lab on a Particle” work.

For more on applications of single cell analysis technologies, read the full open access special issue: Single Cell Analysis Technologies

Visit https://www.slas.org/publications/slas-technology/ for more information about SLAS and its journals.

Join SLAS Podcast Host Dave Pechter as he welcomes R. Graham Cooks, Ph.D. (Purdue University) and Nicolás M. Morato (Purdue University) to discuss their research, featured in the latest Issue of SLAS Technology. They are joined by Nathan P. Coussens, Ph.D. (Frederick National Laboratory for Cancer Research), guest editor of this special issue.  

Together, they discuss the article “Automated High-Throughput System Combining Small-Scale Synthesis with Bioassays and Reaction Screening”. This work explores the application of desorption electrospray ionization (DESI) for high-throughput synthetic chemistry, chemical reaction screening, and label-free biological assays.

This article is part of the December Special Issue: “Assay Guidance Manual for Drug Discovery: Technologies that Matter”, part of a joint collaboration between the Assay Guidance Manual and SLAS. The goal of these combined publications is to tackle the crisis of reproducibility in biomedical science by utilizing rigorous data analysis, strong reporting standards and robust assays. 

The Assay Guidance Manual is a free and publicly available eBook of best practices for the design, development, and implementation of robust assays in preclinical research.

For more information about the journal, visit the SLAS Technology website or contact the SLAS publishing office at publishing@slas.org