The Cancer Clear and Simple podcast, hosted by Joshua Wright, introduces the Cancer Health Disparities Initiative (CHDI) at the University of Wisconsin-Madison Carbone Cancer Center. The CHDI aims to reduce inequities and the cancer burden through research, outreach, education, and training. The conversation explores the underserved populations in Wisconsin, including African Americans, Latinx, American Indian, Hmong, LGBTQ+, and rural communities. These populations face social determinants of health that contribute to lower screening rates, higher cancer incidence, later diagnosis, and higher mortality. The podcast discusses the importance of increasing cancer disparities-related research, both locally and internationally, and highlights the benefits of cancer-focused community outreach and education in rural settings. The goal is to promote health equity, improve access to care, and reduce the burden of cancer for underserved populations. The podcast also emphasizes the importance of trust, collaboration, and patient navigation in clinical research and community engagement. The conversation concludes by inviting listeners to join future episodes and engage in the conversation about cancer disparities.