Friends,

I recently sat down with Dr. Colleen Cutcliffe, CEO of Pendulum Therapeutics, for a discussion about probiotics, metabolism, and a potential natural alternative to GLP-1 drugs like Ozempic. Here's why I'm excited to share this with you...

The Backstory

A month ago, I ran into a friend who had slimmed down and was looking fit. These days, I’ve had a good dozen or so friends lose weight with GLP-1 drugs, so I was surprised when she told me it wasn’t Ozempic but Pendulum's new GLP-1 probiotic. Her chocolate cravings (her usual downfall) had changed entirely. Instead of demolishing a whole bar, she could have one bite and walk away satisfied.

I've known Pendulum for years (we invested at True), and I've personally used their glucose control product with great success. However, I had lost touch with Colleen and didn’t realize they had a new GLP-1 product — so I asked her to come on the podcast and discuss it.

Note: Peter Attia did a much longer and more thorough deep-dive with Colleen, found here

What Makes This Different?

In my interview with Colleen, she explained how their probiotic actually helps your body produce its own GLP-1 hormone naturally. The science is fascinating – they've identified specific strains of bacteria that, when delivered to your gut's distal colon, help stimulate natural GLP-1 production. No shots, no prescription.

The results are pretty impressive; 91% of users reported reduced food cravings after six weeks*, and the higher the initial cravings, the more significant the improvement.

Why This Matters

Over the last year+, I've watched friends scramble to find GLP-1 prescriptions, hitting up sketchy compounding pharmacies, or paying astronomical prices when their insurance won't cover them. It's wild out there.But obesity isn't just about weight – it's tied to heart disease, diabetes, cancer, and even cognitive decline (some scientists are calling Alzheimer's "Type 3 diabetes"). We need better solutions that are both accessible and backed by science.

Join Our Mini-Trial

Here's the exciting part: I’ve worked with Pendulum to create a special trial program exclusively for this newsletter community.

As always, full disclosure: True Ventures, where I work, is an investor in Pendulum. That said, I receive zero compensation for this trial; this is not a paid ad in any capacity.

Here’s why I’m excited to do this:

* I use their products myself (they’ve really helped my gut)

* Friends are now experiencing positive results

* I love the idea of an affordable natural solution

My most valuable asset is your trust. That's why I worked with Colleen to offer a 100-day money-back guarantee (they avoid this due to potential abuse/fraud). If you try it and come back saying, "Kevin, this did nothing for me," email Pendulum, and you'll get a refund. Simple as that.

Here's what you'll get in the trial

* Food Cravings Inventory diagnostic test at 0, 45, and 90 days to track your progress

* Direct access to microbiome specialists (bypassing regular customer service)

* 20% discount on your next order if you see positive results

* Contribute to real-world research data

* 100-day money-back guarantee

How to Join

Quick heads up on how this works: You'll need to purchase a 90-day supply upfront, but using my link unlocks the full money-back guarantee if it doesn't work for you – this is something not available anywhere else on their site. Click here to get started. (you must use this link)

What's Next?

We'll be collecting data throughout the trial and sharing the results with participants. Stay tuned for updates on how the community is progressing.

Exciting stuff ahead! As always, I'd love to hear your thoughts and experiences if you decide to participate.

Until next time, be well,

*based on a consumer survey of 274 people

This is the podcast of the full article found here.

Very Important Note:All future episodes of Diggnation will be posted to the official Diggnation channels, not here on the Kevin Rose Show feed. Get your favorite feed (Youtube, Spotify, Apple, RSS) right here on the new website — www.diggnation.show

Also, looking for fun clips?

* Diggnation Instagram

* Diggnation TikTok

In this captivating episode of The Random Show, Tim Ferriss and Kevin Rose reunite for a freewheeling conversation that spans cutting-edge science, personal growth, and technological marvels. The duo dives into Tim's recent sabbatical, exploring the creative process behind his upcoming book and the challenges of maintaining work-life balance. They candidly discuss their experiences with alternative therapies, including Kevin's intriguing foray into ketamine treatment and Tim's insights on ayahuasca ceremonies, offering a nuanced perspective on these controversial topics.

The conversation takes several unexpected turns, from the latest breakthroughs in AI-generated imagery (complete with amusing demonstrations) to the potential game-changing impacts of the protein Klotho on cognitive health and longevity. Tim and Kevin also open up about their personal lives, touching on the complexities of modern dating, the pursuit of mindfulness, and the ongoing quest to find meaning in a rapidly changing world. Packed with practical advice, thought-provoking ideas, and plenty of laughs, this episode showcases why The Random Show is a source of inspiration and entertainment for listeners seeking to expand their horizons.

Links From the Show

* Fino Toothbrush

* Blood Meridian by Cormac McCarthy

* The Bear by Andrew Krivak

* The Well of Being: A Children’s Book for Adults

* The Birth of Sake (Documentary)

* Outdoorsman Atlas Trainer Frame System

* PicStudio.ai

Show Chapters

[00:00] - Introduction and Opening Banter

[01:00] - Tim's Podcast Sabbatical and Book Writing

[04:00] - AI Image Generation Demonstration

[09:10] - Discussion on Podcasting Challenges and Future

[10:00] - Kevin Demonstrates Fino Toothbrush Device

[13:30] - Kevin's Vampire Facial Experience

[18:20] - Tim's Dating Life and Approach

[24:40] - Recommendations: Books, Documentaries, and Media

[29:50] - Ketamine Therapy Discussion

[35:30] - Klotho Protein and Alzheimer's Research

[41:20] - Funding Scientific Research

[45:00] - Tim's Experiences with Ayahuasca and Supernatural Phenomena

[51:30] - The Birth of Sake Documentary

[54:15] - High Ren Music Video Recommendation

[56:40] - Matthew Perry and Ketamine Risks

[62:00] - Kevin's Experience with a Medium

[68:30] - Tim's Thoughts on Balance and Leisure

[73:50] - Debate on "Chilling Out" and Personal Growth

[79:00] - Closing Thoughts and Show Wrap-up

Buckle up; in this episode, we explore the emerging field of ketamine therapy for mental health treatment with Dr. Jennifer Ellice, a board-certified emergency physician based in Los Angeles. Dr. Ellice, who studied at Princeton University and the University of Rochester School of Medicine before completing her residency at the Warren Alpert Medical School of Brown University, brings extensive experience in emergency medicine since 2008 to her current specialization in ketamine therapy as the Co-Founder of Golden Afternoon.

The conversation delves into ketamine's potential for treating depression, anxiety, PTSD, and chronic pain while addressing common misconceptions and safety concerns. Dr. Ellice discusses the medical applications of ketamine beyond its traditional use as an anesthetic, drawing on her diverse medical background.

Viewers will gain access to the clinical process, from patient screening to administration methods, and witness an unprecedented insider's view as Kevin allows cameras to document his experience during a live ketamine booster therapy session. This rare, unfiltered look into an actual treatment aims to demystify the process, reduce stigma, and potentially help those suffering from mental health issues see ketamine therapy as a viable option. Kevin's willingness to share this deeply personal experience underscores the importance of open dialogue about mental health treatments and advancing public understanding of innovative therapies.

This episode aims to provide a balanced, scientific perspective on a promising but complex treatment option in modern psychiatry, guided by Dr. Ellice’s unique blend of emergency medicine expertise and cutting-edge mental health treatment knowledge.

Links

* Golden Afternoon

* How to Change Your Mind

* Andrew Huberman — Ketamine: Benefits and Risks for Depression, PTSD & Neuroplasticity

Show Topics

* Introduction to Dr. Jennifer Ellis and her credentials

* Overview of ketamine's history in medicine

* Explanation of ketamine as an anesthetic and its use in emergency medicine

* Introduction to ketamine's potential for treating mental health conditions

* Discussion of ketamine's effects on the brain and neuroplasticity

* Comparison of ketamine to traditional antidepressants

* Explanation of different administration methods (IV, intramuscular, intranasal)

* The importance of proper dosing and medical supervision

* Description of a typical ketamine therapy session

* Addressing safety concerns and potential side effects

* Discussion of ketamine's addictive potential

* The concept of "time on brain" and why it matters in treatment

* Exploration of ketamine's effectiveness for various conditions (depression, anxiety, PTSD, chronic pain)

* The role of set and setting in ketamine therapy

* Integration of ketamine therapy with other forms of treatment

* The importance of patient screening and selection

* Legal status and insurance coverage for ketamine therapy

* Potential future developments in ketamine therapy and psychedelic medicine

* Kevin’s first-hand account of a ketamine therapy session

* Post-session integration and the importance of follow-up care

* Discussion of potential long-term effects and benefits of ketamine therapy

The following podcast is a conversation with my friend and colleague Chris Hutchins. In this episode, we discuss a long-form article I just published on my investing playbook. The title of the article is "The Calculated Contrarian: Extreme Security, Extreme Risk, Extraordinary Returns."View the full article hereMore on Chris and his podcast here.

Remember, this is my personal playbook. I'm sharing it for information purposes only, not financial advice. You should always consult with a professional financial advisor before making investment decisions.

The article is broken into several sections:* Timing the Market* How I think about investing bucket allocations* Where I Invest* Index Fund* Bonds and Cash Management: My Financial Shock Absorbers* High-risk* Stock Picking* Risk Management and the Importance of a Moat* Angel Investing: The High-Stakes Poker of Investing* Gold and Bitcoin: Your Financial Apocalypse Insurance* The Importance of Self-Custody and Physical Redemption* Retirement Accounts* When to Buy More* Conclusion

www.kevinrose.com

Dream reading is no longer science fiction. Sleep damage reversal could be a reality. And nightmares? They might become controllable. Dr. Matt Walker unveils these groundbreaking possibilities in sleep science. From antioxidant therapies (Kevin is backing a study here) to brain-zapping sleep enhancers, we're exploring innovations that are revolutionizing our understanding of sleep.

Dr. Matt Walker, is the Professor of Neuroscience and Psychology at UC Berkeley and founder of the Center for Human Sleep Science.

Links from the episode:- Kevin’s SubStack Newsletter- Why We Sleep Org (nonprofit)- Oura Ring- Somnee Sleep Device

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Topics with timestamps:

Topics with timestamps:

[00:00:00] - Introduction and catching up[00:04:40] - Changes in sleep science since Dr. Walker's book publication [00:19:30] - Predicting dreams using brain scanning and machine learning [00:25:20] - The function of dreaming and emotional processing [00:31:20] - Clinical approaches to preventing nightmares [00:35:30] - Ethical concerns about dream prediction technology [00:38:50] - Sleep quality benchmarks and content-based measurements [00:42:40] - Updates on caffeine consumption and sleep [00:52:30] - Temperature regulation for better sleep [01:00:00] - Sleep trackers: accuracy and best practices[01:07:40] - Kevin to fund the sleep study through Substack subscribers [01:09:00] - Details on how listeners can contribute to funding the study[01:12:10] - Discussion of a parasympathetic nervous system stimulation device [01:13:30] - Explanation of the vagus nerve and its role in sleep[01:19:00] - Supplements and sleep aids: what works and what doesn't [01:24:30] - Sex, self-stimulation, and sleep quality [01:27:30] - The impact of sauna usage on sleep (potential future study) [01:32:40] - Brain stimulation techniques for enhancing sleep[01:00:50] - Proposal for a study to mitigate sleep deprivation effects [01:04:00] - Discussion of potential funding methods[01:07:40] - Breakdown of the proposed sleep deprivation study methodology[01:54:30] - Introduction to, StimScience, and the Somnee device [02:05:40] - Closing remarks and information on Dr. Walker's sleep foundation