• The Modified Bohr Equation

  • 2024/02/11
  • 再生時間: 18 分
  • ポッドキャスト

The Modified Bohr Equation

  • サマリー

  • Hosts:

    • Pradip Kamat, Children’s Healthcare of Atlanta/Emory University School of Medicine
    • Rahul Damania, Cleveland Clinic Children’s Hospital

    Case Introduction:

    • 6-year-old patient admitted to PICU with severe pneumonia complicated by pediatric Acute Respiratory Distress Syndrome (pARDS).
    • Presented with respiratory distress, hypoxemia, and significant respiratory acidosis.
    • Required intubation and mechanical ventilation.
    • Despite initial interventions, condition remained precarious with persistent hypercapnia.

    Physiology Concept: Dead Space

    • Defined as the volume of air that does not participate in gas exchange.
    • Consists of anatomic dead space (large airways) and physiologic dead space (alveoli).
    • Physiologic dead space reflects ventilation-perfusion mismatch.

    Pathological Dead Space:

    • Occurs due to conditions disrupting pulmonary blood flow or ventilation.
    • Common in conditions like pulmonary embolism, severe pneumonia, or ARDS.

    Clinical Implications:

    • Increased dead space fraction (DSF) in PARDS is a prognostic factor linked to severity and mortality.
    • Elevated DSF indicates worse lung injury and inefficient gas exchange.
    • DSF can be calculated using the formula: DSF = (PaCO2 – PetCO2) / PaCO2.

    Practical Management:

    • Optimize Mechanical Ventilation
    • Enhance Perfusion
    • Consider Positioning (e.g., prone positioning)

    Summary of Physiology Concepts:

    • Bohr equation for physiologic dead space.
    • Importance of lung-protective ventilation strategies.
    • Monitoring and trending dead space fraction.
    • Strategies to improve airway patency and mucociliary clearance.

    Connect with us!

    • PICU Doc on Call provides concise explanations of critical concepts in pediatric intensive care.
    • Feedback, subscriptions, and reviews are encouraged.
    • Visit picudoconcall.org for episodes and Doc on Call infographics.
    続きを読む 一部表示

あらすじ・解説

Hosts:

  • Pradip Kamat, Children’s Healthcare of Atlanta/Emory University School of Medicine
  • Rahul Damania, Cleveland Clinic Children’s Hospital

Case Introduction:

  • 6-year-old patient admitted to PICU with severe pneumonia complicated by pediatric Acute Respiratory Distress Syndrome (pARDS).
  • Presented with respiratory distress, hypoxemia, and significant respiratory acidosis.
  • Required intubation and mechanical ventilation.
  • Despite initial interventions, condition remained precarious with persistent hypercapnia.

Physiology Concept: Dead Space

  • Defined as the volume of air that does not participate in gas exchange.
  • Consists of anatomic dead space (large airways) and physiologic dead space (alveoli).
  • Physiologic dead space reflects ventilation-perfusion mismatch.

Pathological Dead Space:

  • Occurs due to conditions disrupting pulmonary blood flow or ventilation.
  • Common in conditions like pulmonary embolism, severe pneumonia, or ARDS.

Clinical Implications:

  • Increased dead space fraction (DSF) in PARDS is a prognostic factor linked to severity and mortality.
  • Elevated DSF indicates worse lung injury and inefficient gas exchange.
  • DSF can be calculated using the formula: DSF = (PaCO2 – PetCO2) / PaCO2.

Practical Management:

  • Optimize Mechanical Ventilation
  • Enhance Perfusion
  • Consider Positioning (e.g., prone positioning)

Summary of Physiology Concepts:

  • Bohr equation for physiologic dead space.
  • Importance of lung-protective ventilation strategies.
  • Monitoring and trending dead space fraction.
  • Strategies to improve airway patency and mucociliary clearance.

Connect with us!

  • PICU Doc on Call provides concise explanations of critical concepts in pediatric intensive care.
  • Feedback, subscriptions, and reviews are encouraged.
  • Visit picudoconcall.org for episodes and Doc on Call infographics.

The Modified Bohr Equationに寄せられたリスナーの声

カスタマーレビュー:以下のタブを選択することで、他のサイトのレビューをご覧になれます。