The Parkinson’s Research Podcast: New Discoveries in Neuroscience

著者: The Michael J. Fox Foundation for Parkinson’s Research
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  • In this podcast, The Michael J. Fox Foundation for Parkinson’s Research brings you right to the cutting edge of neuroscience to discuss the latest discoveries in the field of neuroscience, with a focus on Parkinson’s disease (PD). We are working at the forefront of PD research to accelerate scientific breakthroughs by providing funding opportunities, tools and resources to develop new treatments, find cures and improve quality of life for people living with Parkinson’s disease. If you’re a scientist, clinician or industry professional interested in gaining in-depth insights into the latest advances in basic science, translational research and clinical trials for new therapies and therapeutics, this show is for you. Our host Dr. Marie McNeely interviews experts on topics such as the impacts of genetics, mechanisms of neurodegeneration, neuroimaging, biomarkers, diagnostics, applications of machine learning and artificial intelligence, drug development, novel treatment technologies and more. Subscribe to stay up to date on key developments in neuroscience, neurology, neurodegeneration and Parkinson’s disease research.
    Copyright 2024 The Michael J. Fox Foundation for Parkinson’s Research
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あらすじ・解説

In this podcast, The Michael J. Fox Foundation for Parkinson’s Research brings you right to the cutting edge of neuroscience to discuss the latest discoveries in the field of neuroscience, with a focus on Parkinson’s disease (PD). We are working at the forefront of PD research to accelerate scientific breakthroughs by providing funding opportunities, tools and resources to develop new treatments, find cures and improve quality of life for people living with Parkinson’s disease. If you’re a scientist, clinician or industry professional interested in gaining in-depth insights into the latest advances in basic science, translational research and clinical trials for new therapies and therapeutics, this show is for you. Our host Dr. Marie McNeely interviews experts on topics such as the impacts of genetics, mechanisms of neurodegeneration, neuroimaging, biomarkers, diagnostics, applications of machine learning and artificial intelligence, drug development, novel treatment technologies and more. Subscribe to stay up to date on key developments in neuroscience, neurology, neurodegeneration and Parkinson’s disease research.
Copyright 2024 The Michael J. Fox Foundation for Parkinson’s Research
エピソード
  • 26: An Inside Look at the Edmond J. Safra Fellowship in Movement Disorders with Marcelo Merello and Sergio Castillo-Torres
    2024/11/05

    To help meet the growing global need for more movement disorders specialists, The Michael J. Fox Foundation created the Edmond J. Safra Fellowship in Movement Disorders in collaboration with longtime partner the Edmond J. Safra Foundation. This program supports the training of movement disorders specialists who will provide expert care and drive advances in Parkinson's research. The program is positively impacting early-career clinician-researchers, as well as the centers where they train. These impacts will continue to grow over the years as more fellows are trained. In this episode, Dr. Marcelo Merello and Dr. Sergio Castillo-Torres share their insights and perspectives as a Fellowship Director and a Fellow in the program, respectively.

    Marcelo is Director of the Department of Neurosciences and Chief of the Movement Disorders Clinic at the Institute for Neurological Research or Fleni Hospital. He is fellowship Director at Fleni and the University of Buenos Aires. In addition, Marcelo is Principal Investigator with the National Council for Scientific and Technical Research and Professor of Neurodegenerative Diseases at the Pontifical Catholic University of Argentina. Sergio is an Associate Professor in Neurology and Internal Medicine at the Dr. Jose E. Gonzales University Hospital of the Autonomous University of Nuevo Leon. He was an Edmond J. Safra Fellow in Movement Disorders at Fleni Hospital. Visit michaeljfox.org/fellowship to learn more about the Edmond J. Safra Fellowship in Movement Disorders.


    This podcast is geared toward researchers and clinicians. If you live with Parkinson’s or have a friend or family member with PD, listen to The Michael J. Fox Foundation Parkinson’s Podcast. Hear from scientists, doctors and people with Parkinson's on different aspects of life with the disease as well as research toward treatment breakthroughs at https://www.michaeljfox.org/podcasts.

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    58 分
  • 25: Creating Alpha-Synuclein Cell Lines and Supporting Open Science with Birgitt Schüle
    2024/10/15

    Stem cell models derived from patients with Parkinson’s disease are valuable tools that are helping researchers around the world to better understand the underlying causes of neurodegeneration and to develop biomarkers and new therapies. To maximize the potential impacts of these tools, it is critical that they are developed and shared according to the principles of open science. In her interview, Dr. Birgitt Schüle discusses her work developing alpha-synuclein cell lines, challenges and opportunities in the field, and important considerations surrounding open science. She goes in-depth on how the cell lines were developed, characterized, and deposited with the American Tissue and Cell Collection (ATCC) with funding support from The Michael J. Fox Foundation, as well as how these cells can be used to fuel future discoveries. Birgitt is an Associate Professor in the Department of Pathology at Stanford University School of Medicine and Co-Director of the Alzheimer’s Disease Research Center, Neuropathology, and Induced Pluripotent Stem Cell (iPSC) Core.

    This podcast is geared toward researchers and clinicians. If you live with Parkinson’s or have a friend or family member with PD, listen to The Michael J. Fox Foundation Parkinson’s Podcast. Hear from scientists, doctors and people with Parkinson's on different aspects of life with the disease as well as research toward treatment breakthroughs at https://www.michaeljfox.org/podcasts.

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    37 分
  • 24: Developing FLEXISyn to Identify and Measure Changes in Alpha-Synuclein in Parkinson's Disease with Judith Steen
    2024/10/01

    New qualitative and quantitative tools are being developed to measure and track changes in proteins relevant for neurodegenerative disease, and these tools have the potential to accelerate drug discovery and clinical trials. In this episode, Dr. Judith Steen discusses her work creating novel qualitative and quantitative tools and workflows at the interface of proteomics and transcriptomics, including their novel FLEXI platform. This platform uses targeted, high- throughput quantitative mass spectrometry to isolate, quantify, and identify molecular changes in proteins. She describes her ongoing project, funded by The Michael J. Fox Foundation, to develop FLEXISyn, which aims to track post-translational changes in alpha-synuclein to better understand how the protein becomes dysfunctional and begins misfolding and forming toxic aggregations in Parkinson's disease. Judith is Associate Professor of Neurology at Harvard Medical School, a member of the Harvard Stem Cell Institute, and Director of the Neuroproteomics Laboratory in the F.M. Kirby Neurobiology Center at Boston Children's Hospital.

    This podcast is geared toward researchers and clinicians. If you live with Parkinson’s or have a friend or family member with PD, listen to The Michael J. Fox Foundation Parkinson’s Podcast. Hear from scientists, doctors and people with Parkinson's on different aspects of life with the disease as well as research toward treatment breakthroughs at https://www.michaeljfox.org/podcasts.

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    36 分

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