• Trial Talk

  • 著者: UCL Minds
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Trial Talk

著者: UCL Minds
  • サマリー

  • The Trial Talk Podcast explores how our work at the MRC Clinical Trials Unit at UCL is improving health in the UK and worldwide. In this new series, we will hear from world-leading experts about the studies we carry out. We will get inside trials on cancer, infections, and neurodegenerative diseases, explore how public and patient involvement is shaping our studies, and discover new ways to run smarter studies.
    © 2023 UCL Minds
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あらすじ・解説

The Trial Talk Podcast explores how our work at the MRC Clinical Trials Unit at UCL is improving health in the UK and worldwide. In this new series, we will hear from world-leading experts about the studies we carry out. We will get inside trials on cancer, infections, and neurodegenerative diseases, explore how public and patient involvement is shaping our studies, and discover new ways to run smarter studies.
© 2023 UCL Minds
エピソード
  • Episode 8: International Clinical Trials Methodology Conference 2024 roundup - Early Careers Edition
    2024/10/31

    At the start of October, lots of the Unit’s clinical trials methodology researchers travelled to Edinburgh, for the 7th International Clinical Trials Methodology Conference (ICTMC). ICTMC is the largest academic-led conference on clinical trials, bringing together trialists from across the globe to present their latest work in trials methodology. This year's conference featured a wide variety of workshops, talks and poster presentations from MRC Clinical Trials Unit researchers. I

    n this latest episode of the Trial Talk podcast, four of the Unit’s early career researchers discuss the work they presented at ICTMC 2024. Gideon Darko Asamoah tells us how he will deliver a core outcome set for trials in severe malaria; Jingyi Xuan describes her project addressing intercurrent events in platform trials; Dongquan Bi discusses the effects of different cluster sizes in cluster trials; and finally, Kate Roberts explains how she aims to improve the wording around consent for accessing trial participants' healthcare records.

    For questions or feedback on the series, message us at mrcctu.engage@ucl.ac.uk
    For more information and to access the transcript: bit.ly/4f9grVi
    As a listener, your opinion is very valuable to us.
    Please help us to improve the podcast in future by filling in this short survey: forms.office.com/e/PjfjQ5Mn6g

    More resources:
    • Developing a core outcome set for severe malaria trials poster: www.mrcctu.ucl.ac.uk/posters/identi…nd-caregivers/
    • Specifying estimands and estimators in trials with complex designs poster: www.mrcctu.ucl.ac.uk/posters/specif…mplex-designs/
    • Demystifying estimands in cluster-randomised trials paper in Statistical Methods in Medical Research: journals.sagepub.com/doi/10.1177/09622802241254197
    • Estimands in cluster-randomised trials paper in International Journal of Epidemiology: academic.oup.com/ije/article/52/1/107/6644521
    • Current practice around the use of estimands in cluster randomised trials, and the impact of informative cluster size on inference poster: www.mrcctu.ucl.ac.uk/posters/curren…on-inferences/
    • ICTMC 2024 Poster 167 – A rap song (Lyrics by Dongquan Bi, beat by David Fitzgerald): youtu.be/s7qZ5TnOlWU?si=iXwfFfSAWwJ-fAmk
    • CrossWord poster: www.mrcctu.ucl.ac.uk/posters/crossw…ing-materials/


    Date of episode recording: 2024-10-30T00:00:00Z
    Duration: 00:25:09
    Language of episode: English
    Presenter:Charlotte Hartley
    Guests: Gideon Darko Asamoah, Jingyi Xuan, Donguan Bi, Kate Roberts
    Producer: Charlotte Hartley

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    25 分
  • Episode 7: Preventing multidrug-resistant tuberculosis
    2024/09/25

    In September 2024, the World Health Organization (WHO) released new guidance on preventative treatment for tuberculosis (TB). Thanks to new evidence from two randomised controlled clinical trials, the WHO now recommends that contacts of people with multidrug-resistant TB take six months of daily levofloxacin. In this episode of the Trial Talk podcast, we find out more about the TB-CHAMP and VQUIN trials. We also learn how the teams came together to combine their data and strengthen their evidence, using new statistical methodologies developed at the MRC Clinical Trials Unit at UCL. The episode features interviews with Anneke Hesseling, Principal Investigator for TB-CHAMP, based at Stellenbosch University, and Trinh Duong, based at the MRC CTU at UCL, the trial statistician for TB-CHAMP and lead for the combined data analysis with VQUIN.

    For questions or feedback on the series, message us at mrcctu.engage@ucl.ac.uk

    For more information and to access the transcript: bit.ly/3XTf8na

    As a listener, your opinion is very valuable to us. Please help us to improve the podcast in future by filling in this short survey: forms.office.com/e/PjfjQ5Mn6g

    Date of episode recording: 2024-09-23
    Duration: 00:32:50
    Language of episode: English
    Presenter: Charlotte Hartley
    Guests: Anneke Hesseling, Trinh Duong
    Producer: Charlotte Hartley

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    33 分
  • Episode 6: The OPTIC study: Patient views on optimising immunotherapy in cancer
    2024/07/01

    Optimisation immunotherapy clinical trials investigate ways of reducing the intensity of immunotherapy cancer treatment. This could be beneficial for patients’ quality of life. But these trials can be challenging to run, as patients may be concerned about the impact that reducing the intensity of treatment could have on the cancer.

    This episode of the Trial Talk podcast focuses on the MRC Clinical Trials Unit at UCL’s OPTIC study, which explores how people with cancer feel about taking part in optimisation immunotherapy trials. Clinical Fellow Sophie Merrick discusses the main barriers that patients face and recommendations to address them.

    Resources:
    •OPTIC study page: www.mrcctu.ucl.ac.uk/studies/all-st…/refine/optic/
    •OPTIC results paper: www.nature.com/articles/s41416-024-02756-x.pdf
    •REFINE podcast episode: on.soundcloud.com/Fe3C76csHkgCg2or5

    For questions or feedback on the series, message us at mrcctu.engage@ucl.ac.uk

    For more information and to access the transcript: bit.ly/4c9SfAr

    As a listener, your opinion is very valuable to us. Please help us to improve the podcast in future by filling in this short survey: forms.office.com/e/PjfjQ5Mn6g

    Date of episode recording: 2024-06-18T00:00:00Z
    Duration: 00:25:23
    Language of episode: English
    Presenter: Berta Terre-Torras
    Guests: Sophie Merrick
    Producer: Berta Terre-Torras

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    25 分

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