-
Why YOU SHOULD combine a Senolytic with your NAD Booster #29
- 2023/09/02
- 再生時間： 12 分
- ポッドキャスト
-
サマリー
activate_samplebutton_t1
あらすじ・解説
I hope you enjoy my content and find it interesting or informative, if so, please consider supporting the channel by using one of the affiliate links below: * Buy me a Kofi: https://ko-fi.com/mynmnexperiment * Patreon: https://bit.ly/3hhfjl5 * SubscribeStar: https://bit.ly/3psYo23Renue by Science 10% Discount Code: MYNMN (https://renuebyscience.com/?rfsn=5692699.331801&coupon-code=MYNMN) Renue by Science 15% Subscription Service Discount Code: MYNMNSUBYouth & Earth 15% Discount Code: MYNMN (https://youthandearth.com?sca_ref=3766764.knrWl4O3cB) ProHealth 15% Discount Code: MYNMN (https://www.prohealth.com/) DoNotAge 10% Discount Code: MYNMN (https://bit.ly/2VBDgNt) Renue by Science 10% Discount Code: MYNMN (https://renuebyscience.com/?rfsn=5692699.331801&coupon-code=MYNMN) Renue by Science 15% Subscription Service Discount Code: MYNMNSUB My Current Anti-Aging Protocol:· 1.5 grams of NMN (https://bit.ly/3c2Fxt8) · 1.5 grams of Trans-resveratrol (Tue, Thu & Sat) (https://bit.ly/3yxeqy2) · 500mg Metformin· 1.5 grams of TMG (https://bit.ly/3oe1Ted) · 5,000 IU (International Units) of vitamin D3 (https://bit.ly/3P32hYH) · 120 mcg (micrograms) of vitamin K2 (Mk 7) (https://bit.ly/3PhkBgn) · 250mg Magnesium (L-Threonate) (https://bit.ly/3O4pZ5o) · 200mg high molecular weight hyaluronic acid (https://bit.ly/3P0Z4c2) · 2,400mg of Fisetin, on the 1st, 2nd & 3rd of each month (https://bit.ly/3P2rSB0) · 2,400mg of Quercetin, on the 1st, 2nd & 3rd of each month (https://bit.ly/3IzulAy)· Quercetin & Fisetin Periodic Dosing (https://bit.ly/3mw1IgN)· 81mg of aspirin (https://bit.ly/3uFjtem) · 800mg SIRT6 Activator (https://bit.ly/3MyfA4J)· 600mg DIM (https://bit.ly/3ZX9NsG)· 800mg GlyNAC (https://shorturl.ac/7b75r) Links:https://singularityhub.com/2020/11/24/another-win-for-senolytics-fighting-aging-at-the-cellular-level-just-got-easier/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7405395/https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(19)30641-3/fulltexthttps://www.nature.com/articles/s42255-020-00305-3https://www.nature.com/articles/s41591-018-0092-9https://www.nature.com/articles/s41591-018-0092-9https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4911708/https://www.nature.com/articles/s41587-020-00750-1https://www.healtheuropa.eu/senolytic-drugs-can-this-antibiotic-treat-symptoms-of-ageing/100585/ Firstly, many thanks to Tao Plakrapong, for sending me a link to this article. This is a review of the article ‘Another Win for Senolytics: Fighting Aging at the Cellular Level Just Got Easier’ by Shelly Fan PhD and some other interesting information on senolytic trials.Links in the description below to the article and the other links I used to make this presentation. Hallmarks of Aging In the article Shelly references the parable of the blind men and the elephant and likens it to Longevity. For those unfamiliar with the parable, in essence blind men who don’t know what an elephant is are asked to touch a different body part and then conceptualize what the animal is like, because of their limited experience and specific area of touch, each man has vastly different conclusion and they all believe that they’re description is correct. She says that aging, thanks to its complexity, is the bio-medical equivalent of the elephant.In that researchers have focused on either one or another “hallmark” of aging, with some success, but not a number together.Joining the DotsFor example, past research has shown us that energy production in our cells can become erratic and non-functional as we age. Cells programmed for apoptosis don’t die, but instead become zombie-like “senescent cells. A "senescent cell" is a cell in our body whose telomeres have reached their "Hayflick Limit" i.e. its telomeres have become so short that the cell cannot divide anymore.It is not a healthy cell anymore, it’s not exactly dead, but it is programmed for death, this cell death is called apoptosis, the Greek for self-eating, if it doesn’t die it starts to produce chemicals that increase inflammation and damage our DNA.The key is to find out how other hallmarks of aging, such as lower NAD, inflammation and shortening telomeres interact with zombie cells, so we can see the whole picture. The StudyA new study published in Nature Metabolism has starting to connect the dots. A study, in mice, linked-up three promising anti-aging pathways· Attacking senescent cells· Addressing inflammation· Tackling unreliable energy production in cellsAll three elements point to one key factor that drives aging. Healthy to Zombie CellShelly likens individual cells to small cities; each with their own power plants and their ‘superstar’ molecular worker is Nicotinamide Adenine Dinucleotide (NAD). As we know NAD...