How do your genes impact your drug response, and what about your metabolism?

In this episode we explain genetic variation impacting drug response or pharmacogenomics and folate requirements in pregnancy.

Variant effect maps are an amazing tool for understanding individual response to diseases and drugs, but normally they are made in one environment, how many environments are needed for us to implement individualized medicine?

We want to thank Dr. Roth, Iris Cohn and Dr. Axford for their participation.

This podcast is a series by the outreach group sponsored by the Atlas of Variant Effects Alliance. Made with love and care by Alex, Evelina, Kortni, Adrine and Moez. Music by Alan Diaz from @⁠⁠_fotorecords_⁠⁠

Our first season runs the gamut from discussing the origins of disease-causing variants to artificial intelligence in genetics to understanding what it takes clinically to reclassify a Variant of Uncertain Significance (VUS) to either disease-causing or benign.

This podcast focuses on a realistic portrayal of the basic and translational research behind rare diseases with the hope that it will lead to better patient care, but this podcast is not meant to be medical advice.
*Disclaimer: brand names mentioned in this podcast are not a direct endorsement by SickKids or the Atlas of Variant Effects. No partnership was established in this episode.

#vuspodcast #genetics #raredisease #varianteffect #atlasofvarianteffects

“Views expressed in the content are solely that of the author(s) and do not necessarily reflect the views of the Atlas of Variant Effects Alliance.”