検索キーワード： 歴史・解説

From the conquest of Mexico by smallpox as much as by the Spanish, to the bubonic plague in China, to the typhoid epidemic in Europe, William H. McNeill's Plagues and Peoples is a brilliantly conceptualized and challenging achievement (Kirkus Reviews). Upon its original publication, Plagues and Peoples was an immediate critical and popular success, offering a radically new interpretation of world history. With the identification of AIDS in the early 1980s, another chapter was added to this chronicle of events, which William McNeill explores in his introduction to this edition.

After his father died, James L. Nolan, Jr., took possession of a box of private family materials. To his surprise, the small secret archive contained a treasure trove of information about his grandfather's role as a doctor in the Manhattan Project. Dr. Nolan, it turned out, had been a significant figure. 

Mark Gober dives into fundamental beliefs about health and disease. These beliefs are so fundamental, in fact, that most of us probably haven’t thought to question them. For example, do bacteria cause disease, or are they part of the body’s cleanup crew that appears at the scene of an underlying toxicity or injury? Do researchers follow the scientific method when they claim to isolate viruses and show that they cause disease in their hosts? In addition to exploring these essential questions, Gober goes a layer deeper by examining the nature of consciousness.

When British-born Elizabeth Blackwell earned her medical degree in America in 1849, there was an international outcry. Few at the time would have disagreed with the actress Fanny Kemble's remark - "What, trust a woman doctor - never!"

Cystic fibrosis was once a mysterious disease that killed infants and children. Now it could be the key to healing millions with genetic diseases of every type - from Alzheimer's and Parkinson's to diabetes and sickle cell anemia. Told from the perspectives of the patients, families, physicians, scientists, and philanthropists fighting on the front lines, Breath from Salt is a remarkable story of unlikely scientific and medical firsts, of setbacks and successes, and of people who refused to give up hope....

He has been called the greatest surgeon of the 20th century. The son of Lebanese immigrants, Michael DeBakey rose from humble beginnings in a backwater Louisiana town to dominate the landscape of modern medicine. His contributions to our understanding and treatment of cardiovascular disease, in particular, were innumerable and epoch-making. DeBakey led a life of high drama, from the streets of Jazz Age New Orleans and the operating theaters of pre-war Europe, to the battlefields of World War II and the floodwaters of Hurricane Katrina.  

Witness early, bloody, anaesthetic-free operations and first crude surgical instruments, trace the mapping of the circulatory system, follow the painstaking detective work that led to the decoding of the human genome and understand the role that potions, cures, therapies, herbal medicines and drugs have played in the human quest to tame and conquer disease, injury and death. An engrossing history and tale of drama and discovery that celebrates the milestones of medical history across generations and cultures.

For two decades, Dr. Danielle Ofri has cared for patients at Bellevue, the oldest public hospital in the country and a crossroads for the world's cultures. In Medicine in Translation she introduces us, in vivid, moving portraits, to her patients, who have braved language barriers, religious and racial divides, and the emotional and practical difficulties of exile in order to access quality health care.

Her name was Henrietta Lacks, but scientists know her as HeLa. She was a poor Southern tobacco farmer who worked the same land as her slave ancestors, yet her cells - taken without her knowledge - became one of the most important tools in medicine: The first “immortal” human cells grown in culture, which are still alive today, though she has been dead for more than 60 years. HeLa cells were vital for developing the polio vaccine; uncovered secrets of cancer, viruses, and the atom bomb’s effects.

To these seven narratives of neurological disorder Dr. Sacks brings the same humanity, poetic observation, and infectious sense of wonder that are apparent in his bestsellers Awakenings and The Man Who Mistook His Wife for a Hat. These men, women, and one extraordinary child emerge as brilliantly adaptive personalities, whose conditions have not so much debilitated them as ushered them into another reality.

By investigating thousands of descriptions of epidemics reaching back before the fifth-century-BCE Plague of Athens to the distrust and violence that erupted with Ebola in 2014, Epidemics challenges a dominant hypothesis in the study of epidemics, that invariably across time and space, epidemics provoked hatred, blaming of the "other", and victimizing bearers of epidemic diseases, particularly when diseases were mysterious, without known cures or preventive measures.

In 1930s and 1940s Vienna, child psychiatrist Hans Asperger sought to define autism as a diagnostic category, aiming to treat those children, usually boys, he deemed capable of participating fully in society. Depicted as a compassionate and devoted researcher, Asperger was in fact deeply influenced by Nazi psychiatry. Although he did offer individualized care to children he deemed promising, he also prescribed harsh institutionalization and even transfer to Spiegelgrund for children with greater disabilities, who, he held, could not integrate into the community.  

In this panoramic account, we learn how great epidemics have not only led to enormous suffering and mass death but also changed the course of history. Humanity has struck back at the microbes: antibiotics and new vaccines have saved millions of lives. But the battle is far from won. We face increasing threats from new and unavoidable pandemics, antibiotic resistance, and even potential extraterrestrial microbes. Duel Without End is a fascinating journey through the long history of infection, from the dawn of life to humanity's future exploration of deep space.

Medicine has become inhuman, to disastrous effect. The doctor-patient relationship - the heart of medicine - is broken: doctors are too distracted and overwhelmed to truly connect with their patients, and medical errors and misdiagnoses abound. In Deep Medicine, leading physician Eric Topol reveals how artificial intelligence can help. AI has the potential to transform everything doctors do, from notetaking and medical scans to diagnosis and treatment, greatly cutting down the cost of medicine and reducing human mortality.

The extraordinary Siddhartha Mukherjee has written a biography of the gene as deft, brilliant, and illuminating as his extraordinarily successful biography of cancer. Weaving science, social history, and personal narrative to tell us the story of one of the most important conceptual breakthroughs of modern times, Mukherjee animates the quest to understand human heredity and its surprising influence on our lives, personalities, identities, fates, and choices.

Human history hinges on the battle to confront our most dangerous enemies—the half-dozen diseases responsible for killing almost all of mankind. The story of our medical triumphs reveals an inspiring tapestry of human achievement, but the journey was far from smooth. It is a tale replete with dramatic episodes as spellbinding as any blockbuster Hollywood movie. In The Masters of Medicine, Dr. Andrew Lam, an award-winning author and retinal surgeon, distills the long arc of medical progress down to the crucial moments that were responsible for the world's greatest medical miracles.

Beginning with the origins of the concept of mania—and the term maniac—in ancient Greek and Roman civilizations, renowned psychiatrist David Healy examines how concepts of mental afflictions evolved as scientific breakthroughs established connections between brain function and mental illness. Healy recounts the changing definitions of mania through the centuries, explores the effects of new terminology and growing public awareness of the disease on culture and society, and examines the rise of psychotropic treatments and pharmacological marketing over the past four decades.

Mosquito Warrior tells the engrossing story of General William C. Gorgas (1854-1920), the once-renowned pioneer in tropical disease research and public health. His fascinating life illuminates vast transformations in the United States. Carol R. Byerly's balanced and contemporary examination of Gorgas illuminates his complex legacy in medicine and public health, military history, and American ambitions at the dawn of United States global ascendency.

Humankind has always wrestled with the existence of suffering. For two centuries, many American ministers, physicians, and scientists believed that an omnipotent and omniscient God created the world such that people might relieve suffering through ingenuity and learning. Others responded to the new worldview introduced by the scientific revolution as a threat to the divine order. In Imagining Progress, Kristin Johnson traces the history of Americans' evolving relationship with science and religion at "one of its most dramatic places"—the bedsides of dying children.

Food and Drug Administration approval for COVID-19 vaccines and the controversial Alzheimer's drug Aduhelm made headlines, but few of us know much about how the agency does its work. Why is the FDA the ultimate United States authority on a drug's safety and efficacy? In Drugs and the FDA, Mikkael Sekeres—a leading oncologist and former chair of the FDA's cancer drug advisory committee—tells the story of how the FDA became the most trusted regulatory agency in the world.