What began as a utopian environment, where mice had sumptuous accommodations, had all the food and water they could want, and were free from disease and predators, turned into a mouse hell. Science writer and animal behaviorist Lee Alan Dugatkin introduces listeners to the work of rodent researcher John Bumpass Calhoun. Dugatkin shows how an ecologist-turned-psychologist-turned-futurist became a science rock star embedded in the culture of the 1960s and 1970s. As interest grew in his rodent cities, Calhoun was courted by city planners and his work was reflected in Tom Wolfe's writing and the children's book Mrs. Frisby and the Rats of NIMH.

Listeners see how Calhoun's experiments led to his concept of "behavioral sinks" with real effects on public policy discussions. Overpopulation in Calhoun's mouse (and rat) complexes led to the loss of sex drive, the absence of maternal care, and a class that included "the beautiful ones," who spent their time grooming themselves while shunning socialization. Calhoun saw this collapse as a harbinger of the ill effects of an overpopulated human world.

Dugatkin offers a riveting account of an intriguing scientific figure. Considering Dr. Calhoun's experiments, he explores the changing nature of scientific research and delves into what the study of animal behavior can teach us about ourselves.