Diabetes Core Update is a monthly podcast that presents and discusses the latest clinically relevant articles from the American Diabetes Association’s four science and medical journals – Diabetes, Diabetes Care, Clinical Diabetes, and Diabetes Spectrum. Each episode is approximately 25 minutes long and presents 5-6 recently published articles from ADA journals.

Intended for practicing physicians and health care professionals, Diabetes Core Update discusses how the latest research and information published in journals of the American Diabetes Association are relevant to clinical practice and can be applied in a treatment setting.

Welcome to diabetes core update where every month we go over the most important articles to come out in the field of diabetes. Articles that are important for practicing clinicians to understand to stay up with the rapid changes in the field.

This issue will review:

1. Insulin Efsitora versus Degludec in Type 2 Diabetes without Previous Insulin Treatment

2. Semaglutide and Opioid Overdose Risk in Patients With Type 2 Diabetes and Opioid Use Disorder

3. Associations of Diabetes and Prediabetes with Mortality and Life Expectancy in China: A National Study

4. GLP-1 Medication Use for Type 2 Diabetes in the US

5. Healthcare Utilization and Cost Associated with Empagliflozin in Older Adults with Type 2 Diabetes

For more information about each of ADA’s science and medical journals, please visitwww.diabetesjournals.org.

Hosts:

Neil Skolnik, M.D., Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University; Associate Director, Family Medicine Residency Program, Abington Jefferson Health

John J. Russell, M.D., Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University; Director, Family Medicine Residency Program, Chair-Department of Family Medicine, Abington Jefferson Health

In this special episode on Oral Health our host, Dr. Neil Skolnik will discuss practical approaches to helping patients achieve oral health which is of critical importance for people with diabetes. His guest for this episode is Dr. Wenche Borgnakke, and expert in public health and dentistry. This special episode is supported by an independent educational grant from Haleon.

Presented by:

Neil Skolnik, M.D., Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University; Associate Director, Family Medicine Residency Program, Abington Jefferson Health

Dr. Wenche Borgnakke. Dr Borgnakke, DDS, MPH, PhD , Adjunct Clinical Assistant Professor of Dentistry in the department of Periodontics and Oral Medicine at the University of Michigan School of Dentistry.

References:

Diabetes Core Update is a monthly podcast that presents and discusses the latest clinically relevant articles from the American Diabetes Association’s four science and medical journals – Diabetes, Diabetes Care, Clinical Diabetes, and Diabetes Spectrum. Each episode is approximately 25 minutes long and presents 5-6 recently published articles from ADA journals.

Intended for practicing physicians and health care professionals, Diabetes Core Update discusses how the latest research and information published in journals of the American Diabetes Association are relevant to clinical practice and can be applied in a treatment setting.

Welcome to diabetes core update where every month we go over the most important articles to come out in the field of diabetes. Articles that are important for practicing clinicians to understand to stay up with the rapid changes in the field.

This issue will review:

1. Finerenone in Heart Failure with Mildly Reduced or Preserved Ejection Fraction

2. Comprehensive Multiple Risk Factor Control in Type 2 Diabetes to Mitigate Heart Failure

3. Efficacy and safety of once-weekly semaglutide 2·4 mg versus placebo in people with obesity and prediabetes (STEP 10)

4. Diabetes, prediabetes, and brain aging: the role of healthy lifestyle

5. Sitting Time and Its Interaction with Physical Activity in Relation to All-Cause and Heart Disease Mortality in U.S. Adults With Diabetes

For more information about each of ADA’s science and medical journals, please visit www.diabetesjournals.org.

Hosts:

Neil Skolnik, M.D., Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University; Associate Director, Family Medicine Residency Program, Abington Jefferson Health

John J. Russell, M.D., Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University; Director, Family Medicine Residency Program, Chair-Department of Family Medicine, Abington Jefferson Health

In this special episode titled “Lipids – Beyond Statins and LDL Cholesterol”, our host, Dr. Neil Skolnik will discuss with two expert guests the details of treatment for LDL-Cholesterol, Triglycerides, and other lipid risk markers. This special episode is supported by an independent educational grant from Amarin.

Presented by:

Neil Skolnik, M.D., Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University; Associate Director, Family Medicine Residency Program, Abington Jefferson Health

James Underberg, M.D. , Clinical Assistant Professor of Medicine at NYU School of Medicine and the NYU Center for Prevention of Cardiovascular Disease, Director of the Bellevue Hospital Lipid Clinic, and Past President of the National Lipid Association.

Layla A. Abushamat, M.D., MPH, Assistant Professor, Department of Medicine in the Division of Atherosclerosis and Vascular Medicine, Baylor College of Medicine, Houston, Texas

Selected references referred to the in the Podcast:

1. Icosapent Ethyl: REDUCE-IT - N Engl J Med 2019; 380:11-22

2. Omega-3 Fatty Acids: STRENGTH trial - JAMA. 2020;324(22):2268-2280

3. Lipoprotein(a) Blood Levels and Cardiovascular Risk Reduction With Icosapent Ethyl. JACC. 2024 Apr, 83 (16) 1529–1539

4. Icosapent ethyl following acute coronary syndrome. European Heart Journal 2024; 45:1173–1176

5. Cardiovascular Disease and Risk Management: ADA Standards of Care in Diabetes—2024. Diabetes Care 2024;47(supp 1): S179–S218

Diabetes Core Update is a monthly podcast that presents and discusses the latest clinically relevant articles from the American Diabetes Association’s four science and medical journals – Diabetes, Diabetes Care, Clinical Diabetes, and Diabetes Spectrum. Each episode is approximately 25 minutes long and presents 5-6 recently published articles from ADA journals.

Intended for practicing physicians and health care professionals, Diabetes Core Update discusses how the latest research and information published in journals of the American Diabetes Association are relevant to clinical practice and can be applied in a treatment setting.

Welcome to diabetes core update where every month we go over the most important articles to come out in the field of diabetes. Articles that are important for practicing clinicians to understand to stay up with the rapid changes in the field.

This issue will review:

1. Age of diabetes diagnosis and lifetime risk of dementia

2. Glucagon-Like Peptide 1 Receptor Agonists and 13 Obesity-Associated Cancers in Patients With Type 2 Diabetes

3. Association of Semaglutide With Tobacco Use Disorder in Patients With Type 2 Diabetes: Target Trial Emulation Using Real-World Data

4. Lowering systolic blood pressure to less than 120 mm Hg versus less than 140 mm Hg in patients with high cardiovascular risk

5. Long-Term Neurobehavioral and Metabolic Outcomes in Offspring of Mothers with Diabetes During Pregnancy

For more information about each of ADA’s science and medical journals, please visitwww.diabetesjournals.org.

Hosts:

Neil Skolnik, M.D., Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University; Associate Director, Family Medicine Residency Program, Abington Jefferson Health

John J. Russell, M.D., Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University; Director, Family Medicine Residency Program, Chair-Department of Family Medicine, Abington Jefferson Health

In this special episode on Low and No Calorie Sweeteners, our host, Dr. Neil Skolnik will take a deep dive into the randomized evidence about the efficacy of Low and No Calorie Sweeteners. Also discussed will be observational trials on NNS, as well as safety. Finally, there will be a discussion of the World Health Organization recommendations on Nonnutritive sweeteners as well as practical clinical insights.

This special episode is supported by an independent educational grant from Heartland Food Group, the maker of the Splenda Group of Products. For more information just go to: www.splenda.com .

Presented by:

Neil Skolnik, M.D., Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University; Associate Director, Family Medicine Residency Program, Abington Jefferson Health

Kathrine Appleton, PhD, Professor of Psychology, Bournemouth University.

Articles discussed:

The effects of low-calorie sweeteners on energy intake and body weight: a systematic review and meta-analyses of sustained intervention studies. Int J Obes (Lond). 2021 Mar;45(3):464-478

Use of non-sugar sweeteners: WHO guideline

Non-nutritive sweeteners and their impacts on the gut microbiome and host physiology. Front Nutr.2022;9:988144

In this special episode recorded live at the American Diabetes Association’s 2024 Scientific Session the hosts of all of ADA’s podcasts – that is Diabetes Care ‘On Air’, DiabetesBio, Diabetes Core Update and Diabetes Day by Day - discuss making podcasts and discuss some of the presentations that they found compelling at the Scientific Sessions. This special episode is supported by an independent educational grant from Bayer.

The group discusses high-impact research presented at the meeting, implications for future research, and clinical considerations and take-aways --- across the “bench-to-beside” spectrum of biomedical research, clinical research, and treatment advances.

More information about ADA’s portfolio of podcasts can be found at: https://diabetesjournals.org/journals/pages/podcasts.

The participants in the live recording include:

• Alice Cheng, MD, chair of ADA’s 2024 Scientific Sessions Planning Committee and co-host of Diabetes Care ‘On Air’
• Kirk Habegger, PhD, cohost of DiabetesBio
• Michael Rickels, MD, MS, cohost of Diabetes Care ‘On Air’
• Darleen Sandoval, PhD, cohost of DiabetesBio
• Neil Skolnik, MD, cohost of Diabetes Core Update and Diabetes Day by Day
• Kevin Williams, PhD, cohost of DiabetesBio

Diabetes Core Update is a monthly podcast that presents and discusses the latest clinically relevant articles from the American Diabetes Association’s four science and medical journals – Diabetes, Diabetes Care, Clinical Diabetes, and Diabetes Spectrum. Each episode is approximately 25 minutes long and presents 5-6 recently published articles from ADA journals.

Intended for practicing physicians and health care professionals, Diabetes Core Update discusses how the latest research and information published in journals of the American Diabetes Association are relevant to clinical practice and can be applied in a treatment setting.

Welcome to diabetes core update where every month we go over the most important articles to come out in the field of diabetes. Articles that are important for practicing clinicians to understand to stay up with the rapid changes in the field.

This issue will review:

1. Effects of Semaglutide on Chronic Kidney Disease in Patients with Type 2 Diabetes

2. Association between the Burden of Microvascular Disease and Cardiorespiratory Fitness

among Adults with Type 2 Diabetes

3. Association of metabolic syndrome with neuroimaging and cognitive outcomes

4. Tirzepatide for the Treatment of Obstructive Sleep Apnea and Obesity

5. Semaglutide and Cardiovascular Outcomes by Baseline HbA and Change

in HbA in SELECT

For more information about each of ADA’s science and medical journals, please visit www.diabetesjournals.org.

Hosts:

Neil Skolnik, M.D., Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University; Associate Director, Family Medicine Residency Program, Abington Jefferson Health

John J. Russell, M.D., Professor of Family and Community Medicine, Sidney Kimmel Medical College, Thomas Jefferson University; Director, Family Medicine Residency Program, Chair-Department of Family Medicine, Abington Jefferson Health