In this illuminating episode of the Longevity India podcast, we're joined by esteemed scientist, Dr. Suresh Rattan, to delve deep into the world of hormesis and its significance in ageing and wellbeing. Key Discussion Points: Understanding Hormesis & Hormetins: Discover the nonlinear biphasic relationship of stress response and how it plays a crucial role in healthy ageing. Challenging Yourself: Learn about achieving and enjoying healthy ageing through hormesis and the positive effects of choosing a mild stress repeatedly. Hormetins and Their Role: Uncover the potential of natural and synthetic compounds, known as hormetins, which can produce hormetic effects by activating stress response pathways. From physical and nutritional to mental hormetins, explore how various practices and substances can fortify our homeodynamic space. About Dr. Suresh Rattan: Dr. Suresh Rattan, an acclaimed academic, earned his D.Sc. from Aarhus University, Denmark in 1995, and Ph.D. from the National Institute for Medical Research, London, UK in 1982. He pursued his M.Phil. from Jawaharlal Nehru University, New Delhi, India in 1979. Under the mentorship of eminent personalities like Robin Holliday, Ian Buchanan, and Sivatosh Mookerjee, he has gained profound expertise in the realm of ageing and homeodynamics. Join us in this episode as we explore the fine line between beneficial and harmful stress, and how understanding this balance can lead us to healthier and longer lives.

In this episode, we are thrilled to host Dr. Pankaj Kapahi, a renowned expert in the realm of aging and gerontology. With a prolific academic journey that began at the University of Manchester under the guidance of Tom Kirkwood, and later took him to work alongside esteemed researchers like Seymour Benzer at Caltech and Michael Karin at the University of California, San Diego, Dr. Kapahi's career has been marked by pioneering research and profound discoveries. Currently associated with the Buck Institute since 2004, Dr. Kapahi's accolades include over 80 scientific papers, three patents, and a slew of awards that bear testament to his dedication and expertise in the field. Among his honors are the Eureka Award from the National Institute on Aging, the New Scholar Award from the Ellison Medical Foundation, the Glenn Award for Research in Biological Mechanisms of Aging, and several others. Apart from his research, Dr. Kapahi is also lauded for introducing the first master’s degree course in gerontology at the Buck Institute and his contributions to esteemed journals like Aging Cell, Aging, and PLOS Genetics. In this podcast episode, Dr. Kapahi delves deep into: The impact and benefits of Dietary Restriction (DR) as a method to extend lifespan and counteract age-related diseases. The parallels between the lifespan-extending effects of inhibiting the TOR pathway and the effects of DR in organisms like D. melanogaster, S. cerevisiae, and C. elegans. The ongoing efforts in the Kapahi lab to comprehend how organisms gauge nutrient status to influence their health and vulnerability to diseases. An insightful exploration of advanced glycation end products - their formation, their detrimental effects on our health, the variety found within the body, and the foods that are rich in these compounds. Fascinating results from experiments on model organisms when the detoxification process of advanced glycation end products was expedited. Join us for a captivating journey into the intricate mechanisms of aging and the potential interventions that promise a longer, healthier life. Don't forget to like, share, and subscribe for more enlightening conversations on the Longevity India Podcast!

In this insightful episode, we are privileged to host Dr. Suresh Ratan, a biogerontologist and an eminent senior scientist at Aarhus University, Denmark. Join us as we journey through the fascinating world of gerontology, understanding its roots, present scenarios, and exciting prospects for the future. 🎙️ Episode Highlights: Hayflick's Paradigm: Dive into the foundational observations that led to the understanding that cells have a finite lifespan, shedding light on the cellular mechanisms behind aging. The Myth of Aging Genes: Dr. Ratan debunks common misconceptions about genes causing aging. Instead, he introduces us to 'gerento genes' - his novel concept suggesting genes that defend us against aging. But like all natural processes, they aren't flawless. The Game of Lifespan: Learn about the intriguing difference between 'essential lifespan' - the period needed for successful reproduction, and 'maximal lifespan' - the ultimate boundary of an organism's life. Did you know humans have an essential lifespan of around 45 years? When Do We Start Aging?: A riveting discussion on the onset of the aging process in humans. Prepare to be surprised! The Enigma of Senescent Cells: Discover the journey of how senescent cells were identified and their role in aging. Plus, get Dr. Ratan's expert take on the emerging field of senolytics. Gut Microbiome & Aging: A brief exploration on how our gut health might be intertwined with the aging process, spotlighting cutting-edge research in this area. Disclaimer: In the episode, there was a mention of there being ten-thousand species of bacteria in our microbiome. To clarify, scientists typically estimate a range of about 300 to one-thousand different species (the exact number is still under research), with the total bacterial count being somewhere around 5 to 10-trillion. Don't forget to Like, Share, and Subscribe for more deep dives into the world of longevity and aging research! Drop your questions and comments below, and we'll ensure to bring more experts like Dr. Ratan to answer them.

Welcome to another fascinating episode of the Longevity India podcast! Join us as we delve into a groundbreaking discussion with Liz Parrish, CEO of Bioviva. Liz, a recognized figure in the field of gene therapy, opens up about her mission to cure ageing and the innovative strides she and her team are making at Bioviva. In this episode, Liz talks about the essence of curing ageing, not only to extend life but also to combat the myriad diseases that come with old age. Discover what gene therapy for longevity is, and learn how gene editing could be our key to reversing biological ageing. Liz shares her personal experience with gene therapy, a unique insight into the potential this revolutionary technology holds. She discusses the effects of telomere gene therapy on other hallmarks of ageing like mitochondrial dysfunction and opens up about the exciting future she sees for gene therapy. Exploring broader aspects of health and longevity, Parrish weighs in on the role of the gut microbiome in dealing with lifestyle diseases and the potential implications of genetic engineering for an improved life quality. Navigating the regulatory landscape is critical for innovation in gene therapy, and Liz shares her views on the challenges and opportunities when it comes to liaising with regulatory bodies. She firmly believes that curing ageing is a solution to address all old age diseases. Beyond medical advancement, Parrish's vision for a longer and healthier life includes exciting goals like exploring other planets, learning music, mastering maths, and more. Check out https://www.bestchoicemedicine.com/ You can make a difference by signing the petition that aids Liz's efforts to appeal to the government to democratize access to new technologies, making them affordable for everyone. Make sure to tune in, like, share and subscribe for more in-depth discussions on longevity and health. #Longevity #GeneTherapy #AntiAging #LizParrish #Bioviva #LongevityIndiaPodcast

In this episode of the Longevity India podcast, we host Aubrey de Grey, president of the Longevity Escape Velocity foundation and well-known researcher in the field of aging and regenerative medicine. We discuss Aubrey's vision for longevity escape velocity, a point at which the rate of aging decline is greater than the rate of aging, leading to indefinite lifespans.

He passionately discussed the profound impact of decelerating the aging process on the global economy. Beginning with a comprehensive definition of the aging process, he eloquently explored the potential characteristics of a longevity protocol once we achieve longevity escape velocity. Throughout his insightful discourse, he touched upon diverse topics related to longevity and slowing down the ageing process.

Aubrey de Grey is a British biomedical gerontologist who is known for his work on strategies for engineered negligible senescence (SENS), a proposed approach to slowing or reversing aging. He is the author of The Mitochondrial Free Radical Theory of Aging and co-author of Ending Aging.

De Grey began his career as a computer scientist, but he switched to biogerontology in the early 1990s. He is the Chief Science Officer of the SENS Research Foundation, a non-profit organization that is dedicated to funding research into SENS. He is also the Editor-in-Chief of the journal Rejuvenation Research.

De Grey is a passionate advocate for life extension. He believes that aging is a curable disease and that it is possible to live for thousands of years. He is a popular speaker and has appeared in a number of media outlets, including TED, CBS 60 Minutes, and The Guardian.

De Grey's work has the potential to have a major impact on human health and longevity. If his research is successful, it could mean that people alive today could live for centuries or even millennia.

👉 Join us in this enlightening episode as we delve deep into the world of gut health and its impact on overall well-being! Our special guest, Janvi Chitalia, a renowned Gut and Functional Nutritionist, brings her expertise and passion for using food as medicine to help heal various gut-related conditions. In this episode, Janvi Chitalia will shed light on the fascinating world of the gut microbiome and the concept of "Leaky Gut." We will explore the intricate connections between gut health and various aspects of our well-being, from digestion and immunity to mental health and skin conditions. Janvi will break down the science behind Leaky Gut, explaining its potential causes and the profound impact it can have on our health. Moreover, she will share valuable insights on how to nurture a healthy gut through a holistic approach, including dietary and lifestyle adjustments. Janvi Chitalia is a dedicated Gut and Functional Nutritionist. With extensive experience in the field, Janvi has helped countless individuals overcome digestive problems, hormonal imbalances, skin & hair-related concerns, autoimmune conditions, and sleep disorders. Her knowledge and insights into the gut's role in overall health have earned her a strong following and recognition within the health and wellness community.

Welcome to Longevity India, the podcast that explores the secrets to living a long, healthy, and fulfilling life! In this episode, we have the privilege of hosting Nidhi Chawla, CEO & Co-founder of Silver Talkies and Co-Author of "Rethink Ageing." Discover how to empower ageing parents by supporting their passions and interests. In this enlightening podcast Nidhi Chawla shares her expertise in helping aging parents find fulfillment and purpose in their golden years. She emphasizes the importance of supporting parents' passions and interests, enabling them to lead a joyful and meaningful life. The agenda of this podcast is to discuss practical strategies for identifying activities that keep aging parents busy and engaged in pursuits that bring them joy and fulfillment. From hobbies and interests to community involvement, we explore the importance of supporting their passions and providing avenues for continued growth and development. We emphasize the significance of understanding what truly motivates aging parents and offer insights on how to empower them to choose their own path. Providing guidance while respecting their autonomy creates an environment that nurtures their sense of independence and self-worth. Throughout the podcast, we share heartwarming stories, practical tips, and invaluable advice on fostering a supportive and loving relationship with aging parents. We believe that by offering the right assistance and creating a positive environment, we can help them lead lives filled with purpose and happiness. Join us in this transformative conversation and gain the tools and inspiration to positively impact the lives of your aging parents. Together, let's ensure their golden years are truly golden.

Welcome to Longevity India, the podcast that explores the secrets to living a long, healthy, and fulfilling life! In this episode, we have the privilege of hosting the brilliant Dr. K. V. Venkatesh, a distinguished professor from the prestigious IIT Bombay.

Join us as Dr. Venkatesh delves into the fascinating world of systems biology, unraveling the intricate connections between various biological systems within our bodies. He explains the concept of systems biology, shedding light on how it allows us to understand and analyze complex biological processes holistically.Another intriguing topic on our agenda is metabolic aging. Dr. Venkatesh explores the phenomenon and its impact on our energy levels as we grow older.

Discover how metabolic aging influences our body's ability to generate and sustain energy, and gain valuable insights into effective strategies for managing and enhancing energy levels as we age gracefully.

Dr. Venkatesh is a distinguished expert in the field of Systems Biology AI with over 30 years of experience. As a first-generation entrepreneur, he has been at the forefront of integrating healthcare and systems modeling using engineering principles to provide innovative solutions to the challenges faced by the healthcare industry. His expertise extends to nutraceuticals, new therapies, alternative treatments, and wellness domains, making his solutions unique and versatile.Recognizing the potential of Systems Biology-based AI in healthcare personalization, Dr. Venkatesh believes that it holds the key to realizing the full potential of big data and high-throughput experiments. He emphasizes the importance of personalized healthcare solutions, considering the genetic, phenotypic, dietary, lifestyle, and environmental variations among individuals. By leveraging his extensive knowledge and experience in modeling various biological problems, Dr. Venkatesh has developed integrated genetic and physiological models at different levels of complexity, culminating in the creation of a groundbreaking 'virtual human' platform.

To bring his vision to life, Dr. Venkatesh established MetFlux Research, an R&D company dedicated to advancing the Investigative Physiology Platform (IPP). This platform enables modeling analysis and data curation for diverse applications in research and development, including drug discovery, product formulation, clinical research analysis, and more. Additionally, it serves the personalization space by offering technology solutions for wellness, preventive health, and disease management.

Furthermore, the platform excels in data intelligence and analytics, providing services such as data curation, deidentification, research intelligence, benchmarking, and data validation, among others.