Join Drs Felicia C. Chow and Karen C. Bloch as they discuss Histoplasma meningitis, meningococcal meningitis, Rocky Mountain spotted fever, tick-borne infections, and free-living amoeba.

Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/985914). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.

Resources

Meningitis https://emedicine.medscape.com/article/232915-overview

In Search of Encephalitis Etiologies: Diagnostic Challenges in the California Encephalitis Project, 1998-2000 https://pubmed.ncbi.nlm.nih.gov/12627357/

Improvement in Diagnosis of Histoplasma Meningitis by Combined Testing for Histoplasma Antigen and Immunoglobulin G and Immunoglobulin M Anti-Histoplasma Antibody in Cerebrospinal Fluid https://pubmed.ncbi.nlm.nih.gov/29020213/

Central Nervous System Histoplasmosis: Multicenter Retrospective Study on Clinical Features, Diagnostic Approach and Outcome of Treatment https://pubmed.ncbi.nlm.nih.gov/29595679/

Use of Clinical and Neuroimaging Characteristics to Distinguish Temporal Lobe Herpes Simplex Encephalitis From Its Mimics https://pubmed.ncbi.nlm.nih.gov/25637586/

Tumor Necrosis Factor Inhibitors https://www.ncbi.nlm.nih.gov/books/NBK482425/

Central Nervous System Infection With Histoplasma capsulatum https://pubmed.ncbi.nlm.nih.gov/31344869/

Efficacy of Cerebrospinal Fluid Beta-D-Glucan Diagnostic Testing for Fungal Meningitis: A Systematic Review https://pubmed.ncbi.nlm.nih.gov/31996446/

An Overview of Next-Generation Sequencing https://www.technologynetworks.com/genomics/articles/an-overview-of-next-generation-sequencing-346532

Clinical Practice Guidelines for the Management of Patients With Histoplasmosis: 2007 Update by the Infectious Diseases Society of America https://pubmed.ncbi.nlm.nih.gov/17806045/

Comparative Evaluation of Isavuconazonium Sulfate, Voriconazole, and Posaconazole for the Management of Invasive Fungal Infections in an Academic Medical Center https://pubmed.ncbi.nlm.nih.gov/30894179/

β-D-Glucan Testing Is Important for Diagnosis of Invasive Fungal Infections https://pubmed.ncbi.nlm.nih.gov/23850953/

Meningococcal Meningitis https://emedicine.medscape.com/article/1165557-overview

Rocky Mountain Spotted Fever (RMSF) https://emedicine.medscape.com/article/228042-overview

Varicella-Zoster Virus (VZV) https://emedicine.medscape.com/article/231927-overview

Hand-Foot-and-Mouth Disease (HFMD) https://emedicine.medscape.com/article/218402-overview

West Nile Virus https://emedicine.medscape.com/article/312210-overview

Tickborne Diseases of the United States https://www.cdc.gov/ticks/tickbornediseases/index.html

Free Living Amebic Infections https://www.cdc.gov/dpdx/freelivingamebic/index.html

The Differential Diagnosis of Hypoglycorrhachia in Adult Patients https://pubmed.ncbi.nlm.nih.gov/24326618/

Join Drs Felicia C. Chow and Sharon Chen as they discuss how to manage Cryptococcus gattii meningitis in immunocompetent patients.

Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/985913). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.

Resources

Meningitis https://emedicine.medscape.com/article/232915-overview

What's New in Cryptococcus gattii: From Bench to Bedside and Beyond https://pubmed.ncbi.nlm.nih.gov/36675862/

Cryptococcosis https://emedicine.medscape.com/article/215354-overview#a6

Risk Factors for Cryptococcus gattii Infection, British Columbia, Canada https://pubmed.ncbi.nlm.nih.gov/21291588/

Analysis of HLA Association in Susceptibility to Infection With Cryptococcus neoformans var. gattii in a Papua New Guinean Population https://pubmed.ncbi.nlm.nih.gov/9776833/

Cerebral Cryptococcomas: A Systematic Scoping Review of Available Evidence to Facilitate Diagnosis and Treatment https://pubmed.ncbi.nlm.nih.gov/35215148/

Pancoast Syndrome https://www.ncbi.nlm.nih.gov/books/NBK482155/

Evaluation of a Cryptococcal Antigen Lateral Flow Assay and Cryptococcal Antigen Positivity at a Large Public Hospital in Atlanta, Georgia https://pubmed.ncbi.nlm.nih.gov/34189154/

Diagnostic Value of Latex Agglutination in Cryptococcal Meningitis https://pubmed.ncbi.nlm.nih.gov/21938253/

Antifungal Therapy and Management of Complications of Cryptococcosis Due to Cryptococcus gattii https://pubmed.ncbi.nlm.nih.gov/23697747/

Clinical Practice Guidelines for the Management of Cryptococcal Disease: 2010 Update by the Infectious Diseases Society of America https://pubmed.ncbi.nlm.nih.gov/20047480/

Consensus Guidelines for the Diagnosis and Management of Cryptococcosis and Rare Yeast Infections in the Haematology/Oncology Setting, 2021 https://pubmed.ncbi.nlm.nih.gov/34937137/

Cryptococcal Immune Reconstitution Inflammatory Syndrome: From Blood and Cerebrospinal Fluid Biomarkers to Treatment Approaches https://pubmed.ncbi.nlm.nih.gov/33514007/

EORTC/MSGERC Definitions of Invasive Fungal Diseases: Summary of Activities of the Intensive Care Unit Working Group https://pubmed.ncbi.nlm.nih.gov/33709127/

What do slugs, unpasteurized cheeses, and medical tourism vacations have in common? Join experts Drs Felicia Chow and Christina Coyle as they discuss diagnosing meningitis in the returning traveler.

Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/985912). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.

Resources

Meningitis https://emedicine.medscape.com/article/232915-overview

Meningococcal Meningitis https://emedicine.medscape.com/article/1165557-overview

Herpes Simplex Encephalitis https://emedicine.medscape.com/article/1165183-overview

African Tick Bite Fever (ATBF) https://www.cdc.gov/ticks/tickbornediseases/abroad.html

Malaria https://emedicine.medscape.com/article/221134-overview

Listeria Infection https://emedicine.medscape.com/article/965841-overview

West Nile Virus https://www.cdc.gov/westnile/healthcareproviders/index.html

Japanese Encephalitis Virus https://www.cdc.gov/japaneseencephalitis/healthcareproviders/index.html

Leptospirosis https://emedicine.medscape.com/article/220563-overview

Eosinophilic Meningitis https://pubmed.ncbi.nlm.nih.gov/23829911/

Angiostrongylus cantonensis https://www.cdc.gov/parasites/angiostrongylus/health_professionals/index.html

Gnathostomiasis https://emedicine.medscape.com/article/998278-overview

Paratenic Host https://www.oxfordreference.com/display/10.1093/oi/authority.20110803100305869;jsessionid=1FA6B34A6ABEF31CA4EE00426E24F9F1

Baylisascaris https://www.cdc.gov/parasites/baylisascaris/health_professionals/index.html

Coccidioidomycosis and Valley Fever https://emedicine.medscape.com/article/215978-overview

Cryptococcus gattii Infections https://pubmed.ncbi.nlm.nih.gov/25278580/

Fungal Meningitis Outbreak Associated With Procedures Performed Under Epidural Anesthesia in Matamoros, Mexico https://www.cdc.gov/hai/outbreaks/meningitis-epidural-anesthesia.html

What do you do when there are little data to guide your decision-making? Tune in to hear Drs Felicia Chow, Regan R. Solomons and Kelly E. Dooley discuss managing complicated cases of TBM.

Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/985911). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.

Resources

Comparative Effectiveness of Regimens for Drug-Susceptible Tuberculous Meningitis in Children and Adolescents: A Systematic Review and Aggregate-Level Data Meta-Analysis https://pubmed.ncbi.nlm.nih.gov/35673608/

Shortened Tuberculosis Treatment Regimens: What Is New? https://pubmed.ncbi.nlm.nih.gov/32215450/

WHO Consolidated Guidelines on Tuberculosis: Module 5: Management of Tuberculosis in Children and Adolescents https://www.who.int/publications/i/item/9789240046764

Trial of a Six-Month Regimen of High-Dose Rifampicin, High-Dose Isoniazid, Linezolid, and Pyrazinamide Versus a Standard Nine-Month Regimen for the Treatment of Adults and Adolescents With Tuberculous Meningitis https://clinicaltrials.gov/ct2/show/NCT05383742

Randomized Clinical Trial of High-Dose Rifampicin With or Without Levofloxacin Versus Standard of Care for Pediatric Tuberculous Meningitis: The TBM-KIDS Trial https://pubmed.ncbi.nlm.nih.gov/35291004/

Dose-Escalation Study of Isoniazid in Healthy Volunteers With the Rapid Acetylator Genotype of Arylamine N-Acetyltransferase 2 https://pubmed.ncbi.nlm.nih.gov/17665185/

Role of Aspirin in Tuberculous Meningitis: A Systematic Review and Meta-analysis https://pubmed.ncbi.nlm.nih.gov/31512620/

Tumor Necrosis Factor Antagonists for Paradoxical Inflammatory Reactions in the Central Nervous System Tuberculosis: Case Report and Review https://pubmed.ncbi.nlm.nih.gov/33120751/

Pretomanid in the Treatment of Patients With Tuberculosis in the United States https://pubmed.ncbi.nlm.nih.gov/36053513/

Dynamic 18F-Pretomanid PET Imaging in Animal Models of TB Meningitis and Human Studies https://pubmed.ncbi.nlm.nih.gov/36581633/

A Phase 2 Trial to Evaluate the EBA, Safety and Tolerability of Eto Alone and in Combination With BVL-GSK098 (BETO) https://clinicaltrials.gov/ct2/show/NCT05473195

Join experts Drs Felicia Chow and Karen Roos as they discuss the diagnosis and treatment of Lyme meningitis and other emerging neuroborreliosis.

Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/985910). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.

Resources

Lyme Disease https://emedicine.medscape.com/article/330178-overview

Epidemiology of Lyme Disease https://pubmed.ncbi.nlm.nih.gov/36116831/

Regions Where Ticks Live https://www.cdc.gov/ticks/geographic_distribution.html

Arboviral Central Nervous System Infections https://pubmed.ncbi.nlm.nih.gov/33899755/

Lyme Neuroborreliosis: Known Knowns, Known Unknowns https://www.medscape.com/viewarticle/980395_5

Cerebrospinal Fluid Pleocytosis Level as a Diagnostic Predictor? A Cross-sectional Study https://pubmed.ncbi.nlm.nih.gov/28855847/

Mononeuritis Multiplex https://emedicine.medscape.com/article/316024-overview

Peripheral Neuropathy https://www.ninds.nih.gov/health-information/disorders/peripheral-neuropathy

Enzyme Linked Immunosorbent Assay https://www.ncbi.nlm.nih.gov/books/NBK555922/

Lyme Disease Workup https://emedicine.medscape.com/article/330178-workup

Western Blot https://www.proteinatlas.org/learn/method/western+blot

Tabes Dorsalis https://www.ncbi.nlm.nih.gov/books/NBK557891/

Lyme Central Nervous System Infection IgG With Antibody Index Reflex, Serum and Spinal Fluid https://microbiology.testcatalog.org/show/LNBAB

Preventing Tick Bites https://www.cdc.gov/lyme/prev/index.html

Hard Tick Relapsing Fever https://www.cdc.gov/ticks/tickbornediseases/hard-tick-relapsing-fever.html

Rituximab https://www.ncbi.nlm.nih.gov/books/NBK564374/

Join Drs Felicia Chow and Rodrigo Hasbun as they discuss the latest in diagnosis and treatment of bacterial meningitis.

Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/985909). The topics and discussions are planned, produced, and reviewed independently of advertisers. This podcast is intended only for US healthcare professionals.

Resources

Meningitis Treatment & Management https://emedicine.medscape.com/article/232915-treatment

Epidemiology of Community-acquired Bacterial Meningitis https://pubmed.ncbi.nlm.nih.gov/29176349/

Haemophilus Influenzae Type B Vaccine (Rx) https://reference.medscape.com/drug/acthib-hiberix-haemophilus-influenzae-type-b-conjugate-vaccine-343149

Pneumococcal Vaccine 13-valent (Rx) https://reference.medscape.com/drug/prevnar-13-pneumococcal-vaccine-13-valent-999483

Meningococcal A C Y and W-135 Diphtheria Conjugate Vaccine (Rx) https://reference.medscape.com/drug/menactra-menveo-meningococcal-a-c-y-w-135-diphtheria-conjugate-vaccine-999752

Bacterial Meningitis Imaging https://emedicine.medscape.com/article/341971-overview

Practice Guidelines for the Management of Bacterial Meningitis https://pubmed.ncbi.nlm.nih.gov/15494903/

Cranial Imaging Before Lumbar Puncture in Adults With Community-acquired Meningitis: Clinical Utility and Adherence to the Infectious Diseases Society of America Guidelines https://pubmed.ncbi.nlm.nih.gov/28369295/

Comparison of Four Recommendations Guiding the Use of Neuroimaging in the Management of Bacterial Meningitis https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6808988/

Glasgow Coma Scale https://www.glasgowcomascale.org/

Microbial Aspects and Potential Markers for Differentiation Between Bacterial and Viral Meningitis Among Adult Patients https://pubmed.ncbi.nlm.nih.gov/34115780/

Procalcitonin https://www.ncbi.nlm.nih.gov/books/NBK539794/

C Reactive Protein https://www.ncbi.nlm.nih.gov/books/NBK441843/

Healthcare-associated Ventriculitis: Current and Emerging Diagnostic and Treatment Strategies https://pubmed.ncbi.nlm.nih.gov/33334204/

2017 Infectious Diseases Society of America's Clinical Practice Guidelines for Healthcare-associated Ventriculitis and Meningitis https://pubmed.ncbi.nlm.nih.gov/28203777/

Effect of Antibiotic Pretreatment on Cerebrospinal Fluid Profiles of Children With Bacterial Meningitis https://pubmed.ncbi.nlm.nih.gov/18829794/

Impact of Antibiotic Therapy in the Microbiological Yield of Healthcare-associated Ventriculitis and Meningitis https://pubmed.ncbi.nlm.nih.gov/30899767/

A Risk Score for Identifying Patients at a Low Risk of Bacterial Meningitis Amongst Adults With Cerebrospinal Fluid Leucocytosis and a Negative Gram Stain Result: A Derivation and Validation Study https://pubmed.ncbi.nlm.nih.gov/36220627/

Cerebrospinal Fluid Pleocytosis Level as a Diagnostic Predictor? A Cross-sectional Study https://pubmed.ncbi.nlm.nih.gov/28855847/

Repeat Lumbar Puncture in Adults With Bacterial Meningitis https://pubmed.ncbi.nlm.nih.gov/26802211/

Multiplex Polymerase Chain Reaction https://www.sciencedirect.com/topics/immunology-and-microbiology/multiplex-polymerase-chain-reaction

Dexamethasone in Adults With Bacterial Meningitis https://pubmed.ncbi.nlm.nih.gov/12432041/

Adjunctive Dexamethasone Treatment in Adults With Listeria Monocytogenes Meningitis: A Prospective Nationwide Cohort Study https://pubmed.ncbi.nlm.nih.gov/37007737/

Colistin (Rx) https://reference.medscape.com/drug/colistimethate-sodium-coly-mycin-m-colistin-342578

Daptomycin https://www.ncbi.nlm.nih.gov/books/NBK470407/