Drs Vallerie McLaughlin and Marc Humbert discuss the 2022 guidelines on pulmonary arterial hypertension by the European Society of Cardiology (ESC) and the European Respiratory Society (ERS).

Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/968551). The topics and discussions are planned, produced, and reviewed independently of advertiser. This podcast is intended only for US healthcare professionals.

Resources

Pulmonary Arterial Hypertension https://emedicine.medscape.com/article/303098-overview

2022 ESC/ERS Guidelines for the Diagnosis and Treatment of Pulmonary Hypertension https://academic.oup.com/eurheartj/advance-article/doi/10.1093/eurheartj/ehac237/6673929

Pulmonary Arterial Hypertension Risk Stratification https://www.medscape.com/viewarticle/968547

Pulmonary Function Testing https://emedicine.medscape.com/article/303239-overview

Pulmonary Angiography Technique https://emedicine.medscape.com/article/2116480-overview

Drs Vallerie McLaughlin and Richard Channick discuss the diagnosis and treatment of chronic thromboembolic pulmonary hypertension.

Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/968550). The topics and discussions are planned, produced, and reviewed independently of advertiser. This podcast is intended only for US healthcare professionals.

Resources

Pulmonary Hypertension https://www.medscape.com/answers/303098-93380/what-is-pulmonary-hypertension

Chronic Thromboembolic Pulmonary Hypertension (CTEPH) https://emedicine.medscape.com/article/2500057-overview

Pulmonary Embolism https://emedicine.medscape.com/article/300901-overview

Determinants of Diagnostic Delay in Chronic Thromboembolic Pulmonary Hypertension: Results From the European CTEPH Registry https://erj.ersjournals.com/content/52/6/1801687

Pulmonary Embolism Response Teams: Purpose, Evidence for Efficacy, and Future Research Directions https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6611377

V/Q Scan https://www.medscape.com/answers/300901-8522/how-is-vq-scanning-used-for-the-diagnosis-of-pulmonary-embolism-pe

Multidetector Computed Tomography for Acute Pulmonary Embolism https://www.nejm.org/doi/10.1056/NEJMoa052367

Pulmonary Thromboendarterectomy https://www.medscape.org/viewarticle/556058_4

Dynamic Risk Stratification of Patient Long-term Outcome After Pulmonary Endarterectomy: Results From the United Kingdom National Cohort https://pubmed.ncbi.nlm.nih.gov/27052413/

Balloon Pulmonary Angioplasty in Chronic Thromboembolic Pulmonary Hypertension https://err.ersjournals.com/content/26/143/160119

Balloon Pulmonary Angioplasty as a Treatment in Chronic Thromboembolic Pulmonary Hypertension: Past, Present, and Future https://pubmed.ncbi.nlm.nih.gov/32056029/

Pulmonary Arterial Hypertension Clinical Presentation https://emedicine.medscape.com/article/303098-clinical

Riociguat https://reference.medscape.com/drug/adempas-riociguat-999863

Long-term Clinical Value and Outcome of Riociguat in Chronic Thromboembolic Pulmonary Hypertension https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6396196/

Riociguat Prescribing Information https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/204819s006lbl.pdf

Drs Vallerie McLaughlin and Oksana Shlobin discuss methods of identifying and navigating challenging clinical scenarios in pulmonary arterial hypertension.

Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/968548). The topics and discussions are planned, produced, and reviewed independently of advertiser. This podcast is intended only for US healthcare professionals.

Resources

What Is Pulmonary Hypertension? https://www.medscape.com/answers/303098-93380/what-is-pulmonary-hypertension

What Are the WHO Clinical Classifications of Pulmonary Hypertension? https://www.medscape.com/answers/303098-93381/what-are-the-who-clinical-classifications-of-pulmonary-hypertension

Interstitial Lung Disease: Pathophysiology and Genetic Predisposition https://www.medscape.com/viewarticle/408750

What Is the Role of Pulmonary Function Testing in the Evaluation of Restrictive Lung Disease? https://www.medscape.com/answers/301760-187987/what-is-the-role-of-pulmonary-function-testing-in-the-evaluation-of-restrictive-lung-disease

What Is the Six-Minute Walk Test (6mwt) in Pulmonary Function Testing? https://www.medscape.com/answers/303239-77869/what-is-the-six-minute-walk-test-6mwt-in-pulmonary-function-testing

Respiratory Failure-V/Q Mismatch https://emedicine.medscape.com/article/167981-overview#a4

Efficacy and Safety of Riociguat in Patients With Symptomatic Pulmonary Hypertension (PH) Associated With Idiopathic Interstitial Pneumonias (IIP) (RISE-IIP) https://clinicaltrials.gov/ct2/show/NCT02138825

Pulmonary Veno-Occlusive Disease https://emedicine.medscape.com/article/1464015-overview

Sodium-Glucose Cotransporter 2 Inhibitors: An Overview https://www.medscape.com/viewarticle/892957_9

Treatment Approach to Connective Tissue Disease-Associated Interstitial Lung Disease https://www.sciencedirect.com/science/article/abs/pii/S1471489222000728

Drs Vallerie McLaughlin and Ioana Preston discuss how equations and prediction models guide risk stratification of patients diagnosed with pulmonary arterial hypertension.

Relevant disclosures can be found with the episode show notes on Medscape (https://www.medscape.com/viewarticle/968547). The topics and discussions are planned, produced, and reviewed independently of advertiser. This podcast is intended only for US healthcare professionals.

Resources

Pulmonary Arterial Hypertension https://emedicine.medscape.com/article/303098-overview

REVEAL Registry: Registry to Evaluate Early and Long-term PAH Disease Management https://clinicaltrials.gov/ct2/show/NCT00370214

Predicting Survival in Pulmonary Arterial Hypertension: Insights From the Registry to Evaluate Early and Long-term Pulmonary Arterial Hypertension Disease Management (REVEAL) https://doi.org/10.1161/CIRCULATIONAHA.109.898122

Predicting Survival in Patients With Pulmonary Arterial Hypertension: The REVEAL Risk Score Calculator 2.0 and Comparison With ESC/ERS-Based Risk Assessment Strategies https://doi.org/10.1016/j.chest.2019.02.004

Development and Validation of an Abridged Version of the REVEAL 2.0 Risk Score Calculator, REVEAL Lite 2, for Use in Patients With Pulmonary Arterial Hypertension https://doi.org/10.1016/j.chest.2020.08.2069

REVEAL Lite 2 Risk Calculator https://pahriskcalculatorlt.com/

Brain-Type Natriuretic Peptide (BNP) https://emedicine.medscape.com/article/2087425-overview

2015 ESC/ERS Guidelines for the diagnosis and Treatment of Pulmonary Hypertension: The Joint Task Force for the Diagnosis and Treatment of Pulmonary Hypertension of the European Society of Cardiology (ESC) and the European Respiratory Society (ERS): Endorsed by: Association for European Paediatric and Congenital Cardiology (AEPC), International Society for Heart and Lung Transplantation (ISHLT) https://doi.org/10.1093/eurheartj/ehv317

Risk Assessment in Pulmonary Arterial Hypertension https://erj.ersjournals.com/content/51/3/1702606

A Comprehensive Risk Stratification at Early Follow-up Determines Prognosis in Pulmonary Arterial Hypertension https://doi.org/10.1093/eurheartj/ehx257

Risk Assessment, Prognosis and Guideline Implementation in Pulmonary Arterial Hypertension https://doi.org/10.1183/13993003.00889-2017

Risk Assessment in Pulmonary Arterial Hypertension https://doi.org/10.1183/13993003.02606-2017

Regular Risk Assessment in Pulmonary Arterial Hypertension - A Whistleblower for Hidden Disease Progression https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8888324

A Pragmatic Approach to Risk Assessment in Pulmonary Arterial Hypertension Using the 2015 European Society of Cardiology/European Respiratory Society Guidelines https://openheart.bmj.com/content/8/2/e001725.long

Risk Assessment in Precapillary Pulmonary Hypertension: A Comparative Analysis https://respiratory-research.biomedcentral.com/articles/10.1186/s12931-021-01624-z

Diagnostic and Predictive Value of Right Heart Catheterization-Derived Measurements in Pulmonary Hypertension https://doi.org/10.36740/WLek202103130

Scleroderma https://emedicine.medscape.com/article/331864-overview

COMPERA 2.0: A Refined 4-Strata Risk Assessment Model for Pulmonary Arterial Hypertension https://doi.org/10.1183/13993003.02311-2021

Drs Vallerie McLaughlin and Paul Forfia discuss the diagnosis of PAH. What are the causes and why does it take so long?

Relevant disclosures can be found with the episode show notes on Medscape.com (https://www.medscape.com/viewarticle/968546). The topics and discussions are planned, produced, and reviewed independently of advertiser. This podcast is intended only for US healthcare professionals.

Resources

Pulmonary Arterial Hypertension https://emedicine.medscape.com/article/303098-overview

The 'Great Wait' for Diagnosis in Pulmonary Arterial Hypertension https://onlinelibrary.wiley.com/doi/full/10.1111/resp.13814

Systemic Consequences of Pulmonary Hypertension and Right-Sided Heart Failure https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.116.022362

Management of Coronary Artery Disease and Chronic Stable Angina https://www.medscape.com/viewarticle/881468

What Is Myocardial Ischemia? https://www.medscape.com/answers/352401-192899/what-is-myocardial-ischemia

Chronic Obstructive Pulmonary Disease (COPD) https://emedicine.medscape.com/article/297664-overview

Group 4 Pulmonary Hypertension https://emedicine.medscape.com/article/2500057-overview

Pulmonary Arterial Hypertension in Connective Tissue Disorders: Pathophysiology and Treatment https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6405825

Scleroderma https://emedicine.medscape.com/article/331864-overview

Pulmonary Hypertension Phenotypes in Patients With Systemic Sclerosis https://err.ersjournals.com/content/30/161/210053.long

Mixed Connective-Tissue Disease (MCTD) https://emedicine.medscape.com/article/335815-overview

Systemic Lupus Erythematosus (SLE) https://emedicine.medscape.com/article/332244-overview

Sjogren Syndrome https://emedicine.medscape.com/article/332125-overview

Pulmonary Arterial Hypertension in Patients Infected With the Human Immunodeficiency Virus https://www.sciencedirect.com/science/article/abs/pii/S0733865121000679?via%3Dihub

Portal Hypertension https://emedicine.medscape.com/article/182098-overview

Liver Abnormalities in Pulmonary Arterial Hypertension https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8544777/

Pulmonary Hypertension in Adults With Congenital Heart Disease https://www.sciencedirect.com/science/article/abs/pii/S0733865121000692?via%3Dihub

Atrial Septal Defect https://emedicine.medscape.com/article/162914-overview

Anorexigens and Pulmonary Hypertension in the United States https://linkinghub.elsevier.com/retrieve/pii/S0012-3692(15)32749-5

Methamphetamine and the Risk of Pulmonary Arterial Hypertension https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6880795/

Echocardiography in Pulmonary Arterial Hypertension: Comprehensive Evaluation and Technical Considerations https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8348437/pdf/jcm-10-03229.pdf

Echocardiography https://emedicine.medscape.com/article/1820912-overview

Echocardiography Can Identify Patients With Increased Pulmonary Vascular Resistance by Assessing Pressure Reflection in the Pulmonary Circulation https://www.ahajournals.org/doi/10.1161/circimaging.109.913467

Pulmonary Resistance https://reference.medscape.com/calculator/189/pulmonary-resistance

Right Heart Adaptation to Pulmonary Arterial Hypertension: Physiology and Pathobiology https://www.sciencedirect.com/science/article/pii/S0735109713058701?via%3Dihub

RV Systolic Pressure (TR Jet) https://reference.medscape.com/calculator/200/rv-systolic-pressure-tr-jet

Modified Bernoulli Formula https://reference.medscape.com/calculator/150/modified-bernoulli-equation

Limitations and Strengths of Doppler/Echo Pulmonary Artery Systolic Pressure-Right Heart Catheterization Correlations: A Systematic Literature Review https://onlinelibrary.wiley.com/doi/10.1111/echo.12594

Drs Vallerie McLaughlin and Raymond Benza discuss the classifications and causes of pulmonary hypertension.

Relevant disclosures can be found with the episode show notes on Medscape.com (https://www.medscape.com/viewarticle/968545). The topics and discussions are planned, produced, and reviewed independently of advertiser. This podcast is intended only for US healthcare professionals.

Resources

Pulmonary Arterial Hypertension https://emedicine.medscape.com/article/303098-overview#a4

The Definition of Pulmonary Hypertension: History, Practical Implications and Current Controversies https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8753640/pdf/EDU-0076-2021.pdf

Pulmonary Hypertension https://phassociation.org/types-pulmonary-hypertension-groups/

Group 2 Pulmonary Hypertension https://emedicine.medscape.com/article/2500055-overview

Group 3 Pulmonary Hypertension https://emedicine.medscape.com/article/2500056-overview

Group 4 Pulmonary Hypertension https://emedicine.medscape.com/article/2500057-overview

Predicting Survival in Pulmonary Arterial Hypertension: Insights From the Registry to Evaluate Early and Long-Term Pulmonary Arterial Hypertension Disease Management (REVEAL) https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.109.898122

Evidence-Based Detection of Pulmonary Arterial Hypertension in Systemic Sclerosis: The DETECT Study https://ard.bmj.com/content/73/7/1340