Welcome to episode 24 of the Performance Around The Clock podcast. We resume our series from the Society for Research on Biology Rhythms (SRBR) biennial meeting in San Juan, Puerto Rico. In this episode, we are joined by Dr. Annie Curtis, a professor at the Royal College of Surgeons in Ireland (RCSI), who studies the intersection between circadian rhythms and the immune system. We talk about how the timing of infection affects the immune response and the implications for vaccinations. In addition, we hear about the intriguing role of mitochondria in this immune response. Thanks for listening.

Guest:

Dr. Annie Curtis

Associate Professor

Royal College of Surgeons in Ireland (RCSI)

School of Pharmacy and Biomolecular Sciences

Principal Investigator of the Tissue Engineering Research Group (TERG)

Executive Committee for the Irish Society for Immunology between 2016-2020

L’Oreal Women in Science Fellowship in 2017

SFI Career Development Award in 2017

Irish Research Council Laureate Award in 2018

President of the Irish Society for Immunology 2020-2022

SFI Frontiers Award in 2021

Host:

Dr. Satchin Panda

@SatchinPanda

https://x.com/SatchinPanda

Instagram: @satchin.panda

https://www.instagram.com/satchin.panda/

Links:

Donations: https://panda.salk.edu/giving/

Research: https://www.salk.edu/scientist/satchidananda-panda/

More science: https://mycircadianclock.org/

Welcome to the Performance Around the Clock podcast. In episode 23, we are joined by Dr. Emily Manoogian, one of the foremost experts on Time-Restricted Eating (TRE), to discuss her latest research on TRE in adults with metabolic syndrome. We will explore how to implement TRE and its various benefits. Dr. Manoogian will also share insights on using the myCircadianClock app in her clinical trials to track TRE and other circadian metrics. For more information, you can visit the myCircadianClock website at www.mycircadianclock.org. If you are interested in participating in a Type 2 Diabetes and TRE study, please get in touch with Dr. Manoogian at preventivecvresearch@health.ucsd.edu. Her latest study was published in the Annals of Internal Medicine: (https://pubmed.ncbi.nlm.nih.gov/39348690/). Thank you for tuning in.

Time-Restricted Eating in Adults with Metabolic Syndrome: A Randomized Control Trial

https://www.acpjournals.org/doi/10.7326/M24-0859

Guest:

Dr. Emily Manoogian

Hillblom Fellow, Staff Scientist at the Salk Institute for Biological Studies

X (Twitter): @EmilyManoogian

Clinical Trials with Dr. Pam Taub:

https://cardiology.ucsd.edu/research/labs/taub/research/clinical-trials.html#TRE-x-T2D-Study

myCircadianClock website:

www.mycircadianclock.org

Participate in a Type 2 Diabetes Study by emailing:

preventivecvresearch@health.ucsd.edu

Host:

Dr. Satchin Panda

X (Twitter): @SatchinPanda

https://x.com/SatchinPanda

Instagram: @satchin.panda

https://www.instagram.com/satchin.panda/

Links:

Donations: https://panda.salk.edu/giving/

Research: https://www.salk.edu/scientist/satchidananda-panda/

More science: https://mycircadianclock.org/

Episode 22 of the Performance Around the Clock podcast is another episode from the 2024 Society for Research on Biology Rhythms (SRBR) biennial meeting in San Juan, Puerto Rico. We are honored to host this week’s guest, Dr. Charlotte Förster, who epitomizes perseverance in her long scientific career studying circadian rhythms We’ll talk about her work to understand the circadian clock at the molecular and neuronal level, how the clock synchronizes with the day/night cycles and how the clock controls behavior. You’ll also hear about her fascinating research on the synchronization of menstrual cycles with lunar cycles and its implications. Dr. Förster is a professor in Neurobiology and Genetics at the University of Würzburg. Thank you for listening.

Guest:

Dr. Charlotte Forster

Chronobiology Professor, Neurobiology and Genetics, University of Würzburg

Lab website:

https://www.biozentrum.uni-wuerzburg.de/en/neurogenetics/research/wg-foerster/charlotte-foerster/

Host:

Dr. Satchin Panda

@SatchinPanda

https://x.com/SatchinPanda

Instagram: @satchin.panda

https://www.instagram.com/satchin.panda/

Links:

Donations: https://panda.salk.edu/giving/

Research: https://www.salk.edu/scientist/satchidananda-panda/

More science: https://mycircadianclock.org/

Episode 21 of the Performance Around the Clock podcast comes from the 2024 Society for Research on Biology Rhythms (SRBR) biennial meeting in San Juan, Puerto Rico. This week’s guest is Dr. Achim Kramer who developed an assay (BodyTime) to determine internal circadian time. He talks about the development of the assay and how it can be used in circadian medicine. Dr. Kramer is Head of Chronobiology at Charité – Universitätsmedizin Berlin, the largest research hospital in Europe. Thank you for listening.

Guest:

Dr. Achim Kramer

Head of Chronobiology at Charité – Universitätsmedizin Berlin

Lab website:

https://www.achim-kramer-lab.de/

Body clock test:

https://www.bodyclock.health/

BodyTime

High-accuracy determination of internal circadian time from a single blood sample

https://pubmed.ncbi.nlm.nih.gov/29953415/

Host:

Dr. Satchin Panda

@SatchinPanda

https://x.com/SatchinPanda

Instagram: @satchin.panda

https://www.instagram.com/satchin.panda/

Links:

Donations: https://panda.salk.edu/giving/

Research: https://www.salk.edu/scientist/satchidananda-panda/

More science: https://mycircadianclock.org/

Performance Around the Clock episode 20 comes from the 2024 Society for Research on Biology Rhythms (SRBR) biennial meeting in San Juan, Puerto Rico. We have the pleasure to talk with Dr. Christoph Scheiermann who studies the role of circadian rhythms in immune response and how this impacts health and disease. In particular, he’s known for his research on the recruitment and localization of leukocytes which is under circadian control. This process plays a crucial role in immune response which can be leveraged to improve cancer immunotherapy and vaccination efficacy. Learn more about his impactful research in this episode. Thanks for listening.

Guest:

Dr. Christoph Scheiermann

Full Professor

Department of Pathology and Immunology

Centre Medical Universitaire (CMU)

X (formerly Twitter): @ScheiermannLab

https://twitter.com/ScheiermannLab

Lab webpage:

http://scheiermannlab.de/

Host:

Dr. Satchin Panda

@SatchinPanda

https://x.com/SatchinPanda

Instagram: @satchin.panda

https://www.instagram.com/satchin.panda/

Episode 19 of the Performance Around the Clock podcast comes from the 2024 Society for Research on Biological Rhythms (SRBR) biennial meeting in San Juan, Puerto Rico. We have the honor to talk with one of the pillars of the circadian field - Dr. Joseph Takahashi. Dr. Takahashi pioneered the use of forward genetics and positional cloning in mouse as a tool to discover genes that underlie neurobiology and behavior. His discovery of clock genes led to a description of a conserved circadian clock mechanism in animals. In this podcast, we hear about how his lab discovered and cloned the mouse circadian Clock gene. In addition, we find out how circadian alignment of feeding, daily fasting and caloric restriction can combine to increase longevity.

Dr. Takahashi has authored more than 300+ scientific publications and the recipient of many awards and distinctions including:

The Honma Prize in Biological Rhythms Research

NSF Presidential Young Investigator Award

Searle Scholars Award

Bristol-Myers Squibb Unrestricted Grant in Neuroscience, and the C. U. Ariens Kappers Medal. W. Alden Spencer Award in Neuroscience from Columbia University

Fellow of the American Academy of Arts and Sciences

Member of the National Academy of Sciences

Member of the National Academy of Medicine

Gruber Neuroscience Prize at the Society for Neuroscience

Guest:

Dr. Joseph Takahashi

Chair of the Department of Neuroscience at UT Southwestern Medical Center

Loyd B. Sands Distinguished Chair in Neuroscience

X (formerly Twitter): @CircadianClocks

https://twitter.com/circadianclocks

UT Southwestern profile:

https://profiles.utsouthwestern.edu/profile/105885/joseph-takahashi.html

Lab webpage:

https://labs.utsouthwestern.edu/takahashi-lab

Host:

Dr. Satchin Panda

@SatchinPanda

https://x.com/SatchinPanda

Instagram: @satchin.panda

https://www.instagram.com/satchin.panda/

Links:

Donations: https://panda.salk.edu/giving/

Research: https://www.salk.edu/scientist/satchidananda-panda/

More science: https://mycircadianclock.org/

Episode 18, the final episode from the Cell Symposia meeting on Exercise Metabolism in Lisbon, features Dr. Bret Goodpaster. As the Scientific Director at AdventHealth's Translational Research Institute, Dr. Goodpaster is a leading expert in exercise physiology and metabolism. In this episode, he shares his insights on exercise, muscle, aging, and the athlete’s paradox. We also delve into two major scientific projects - HealthABC (Health, Aging Body and Composition) and MoTrPAC (Molecular Transducers of Physical Activity Consortium). HealthABC explores risk factors for functional decline in older adults, including muscle aging. MoTrPAC is a large consortium created to understand the molecular mechanisms of physical activity on health benefits. We hope you will find this episode intellectually stimulating. Thank you for listening.

Guest: Dr. Bret Goodpaster

Scientific Director at Advent Health’s Translational Research Institute

https://www.adventhealthresearchinstitute.com/team/bret-goodpaster

Host: Dr. Satchin Panda

X (formerly Twitter): @SatchinPanda

https://x.com/SatchinPanda

Instagram: @satchin.panda

https://www.instagram.com/satchin.panda/

Links:

Donations: https://panda.salk.edu/giving/

Research: https://www.salk.edu/scientist/satchidananda-panda/

More science: https://mycircadianclock.org/

Episode 17 of the Performance Around The Clock podcast comes from the Cell Symposia meeting on Exercise Metabolism in Lisbon. We were honored to host Dr. Bente Klarlund Pedersen and to talk about her brilliant career from her seminal research on myokines to "exercise as medicine". Dr. Pedersen also tells us about how she uses her knowledge of exercise to educate the public and effect policy changes. Guest: Dr. Bente Klarlund Pedersen Director of Centre for Physical Activity Research (CFAS) https://www.inflammation-metabolism.dk/ X (formerly Twitter): @benteklarlundp https://x.com/benteklarlundp Host: Dr. Satchin Panda X (formerly Twitter): @SatchinPanda https://x.com/SatchinPanda Instagram: @satchin.panda https://www.instagram.com/satchin.panda/ Links: Donations: https://panda.salk.edu/giving/ Research: https://www.salk.edu/scientist/satchidananda-panda/ More science: https://mycircadianclock.org/