It’s Episode 14 of The Nephron Segment! Join us as we chat with Dr. Mehmet Sukru Sever and Dr. Rasha Rashan and discuss disaster nephrology and kidney care during crises. To summarize Dr. Sever tells us "disasters are inevitable. And All countries around the globe are at risk of disasters, either natural or man made." We discuss what we might learn from prior disasters, what do expect in the future, and what we should do, as a nephrology community, to prepare for the worst.

Nephrons: Matthew Sparks, Samira Farouk

Guests: Mehmet Sukru Sever, Rasha Rashan

1:44: Marmara earthquake (1999)

2:35: Bingöl earthquake (2003)

2:44: Bam earthquake (2003)

2:57: Médecins Sans Frontières (MSF)

4:07: Some of Dr. Sever's Papers

4:35: "Destructive Disasters, trauma, crush injury, and beyond"

9:42: Kidney News 2024 Special Section

13:10: "Disasters & Kidney Care: Pitfalls and Solutions" (Nature Reviews Nephrology 2023)

16:31: "An Overlooked, Possibly Fatal Coronavirus Crisis: A Dire Need for Kidney Dialysis" (New York Times 2020)

19:23: "Nephrology Care in Challenging Circumstances: A Patient's Perspective" (Kidney News 2024)

19:59: Syrian refugee crisis

22:08: Refugees & asylees in the United States

25:49: National Kidney Foundation's "Emergency Resources"

26:35: Announcement: ASN, ISN, ERA Collective Effort (2023)

29:06: "Planet Sets Record for Hottest Day Twice in a Row" (2024)

29:12: A review of CKD of unknown etiology (CKDu)

29:49: UEFA Euro 2024

It’s Episode 13 of The Nephron Segment and it's time for NephMadness! Join us as we chat with transplant nephrologist Dr. Roslyn Mannon & transplant hepatologist Dr. Elizabeth Aby and discuss all things dual-organ transplantation: liver-kidney, pancreas-kidney, kidney after liver, kidney after pancreas, or even kidney alone?! Listen to the end to hear everyone's picks for NephMadness 2024.

And to be clear, Dr. Mannon supported the Kansas City Chiefs before their Super Bowl 58 win.

Submit your NephMadness brackets here (just like March Madness!) by 3/31. Maximize your changes by submitting 2 brackets per email address.

Nephrons: Matthew Sparks, Samira Farouk

Guests: Roslyn Mannon, Lizzie Aby

In Episode 12, Dr. William Cushman, co-investigator of the 2015 SPRINT (Systolic Blood Pressure Intervention) Trial, joins us for a discussion all about hypertension trials, their long history, and what's ahead for research in this space. Too young to remember SPRINT or looking for a "CliffsNotes" of HTN trials? This episode's for you!

Here's a Renal Fellow Network post from 2017 with a link to a cheat sheet of hypertension clinical trial.

Nephrons: Matthew Sparks, Samira Farouk

Guests: William Cushman, Medical Director & Professor, Department of Preventive Medicine, University of Tennessee

Links from the Show:

00:41: Systolic Blood Pressure Intervention Trial (2015)

02:17: VA Cooperative Study (1967)

05:13: ACCORD Study (2010)

06:30: SPRINT MIND (2019)

08:40: Framingham Heart Study (Started 1948)

11:27: Attended vs. unattended blood pressure – learnings beyond SPRINT (2021)

14:03: Systolic Hypertension in the Elderly Program Study (1989)

14:05: Hypertension Detection & Follow Up Program (1979)

15:32: JNC 8 Guidelines (2014)

16:01 AHA/ACC Guidelines (2017)

17:54: Syst-Eur (Treatment of HTN in Patients > 60 y, 1998)

17:54: HYVET (Treatment of HTN in Patients > 80 y, 2008)

18:01: Syst-China (2000)

22:18: AAFP HTN Guidelines (2022)

22:40: KDIGO HTN Guidelines (2021)

25:37: ALLHAT Study (2002)

32:22: Secondary Prevention of Small Subcortical Strokes Trial (SPS3, 2013)

In Episode 11, guests Jordy Cohen & Samir Parikh (and members of the American Society of Nephrology Kidney Week Education Committee) join us for a discussion about Kidney Week 2023 and their careers as physician-scientists. They discuss their journeys to their current careers, what inspired them to pursue nephrology ("beautiful ribbons of anti-GBM"), and share their advice for trainees. 

For more on Kidney Week 2023, here's a Doximity op-ed.

Nephrons: Matthew Sparks, Samira Farouk

Guests: Jordy Cohen, Samir Parikh

Links from the Show:

02:03: PLA2R & Membranous Nephropathy (2009)

04:03: Sflt-1

05:05: FLOW & GLP-1

05:55: ACC HTN Guidelines (2017)

09:33: Bill McKibben Plenary: Too Hot & Inhuman Temperatures

10:45: Climate change & heat stress nephropathy

11:00: Ardem Patapoutian Plenary: How Do You Feel? The Molecules that Sense Touch

13:03: Obesity & RAS Activation (Mice)

Episode 10: Green Nephrology (April 20, 2023)

On Episode 10, we celebrate Earth Day with guests Dr. Katherine Barraclough & Dr. Megha Salani who share with us the startling amount of waste that both hemodialysis and peritoneal dialysis generate, what climate change means for kidney disease, and what we can do to protect our planet and "go green." They also share how they became interested in the burgeoning field of green nephrology, in addition to the considerable carbon footprint associated with KRT. We delved into the pathogenesis of heat induced kidney injury and how climate change is now considered a public health emergency. 

Nephrons: Elinor Mannon, Sam Kant, Matthew Sparks, Samira Farouk 

Guests: Katherine Barraclough, Megha Salani

NephMadness 2020: Green Nephrology Region

NephMadness 2020: The Time for Nephrologists to Tackle Climate Change is Now

Links from the Show:

03:57 Waste associated with hemodialysis treatments 

04:31 Carbon footprint generated by plastic waste in dialysis units

05:34 Pursuing environmentally conscious dialysis 

09:43 Innovative solutions to recycle plastic generated from treatments

10:56 Climate change and chronic kidney disease

11:10-Association between high temperature and acute kidney injury

12:21 Climate change: A Public Heath Emergency

13:08 Climate related increase in kidney stones

16:22 Solar power assisted dialysis 

17:02 Incorporating training in environmental sustainability in medical education

21:07 The ISN Green Nephrology Initiative

On Episode 9, guests Dr. Mitchell Lunn and NephMadness 2023 Transgender Health Region writer Dr. Sehrish Ali join us for a discussion of why the 2 teams in this region should win this year's NephMadness crown: Kidney Care for the Transgender Patient and Gender Affirming Care. We discuss what gender affirming care really means, challenges of glomerular filtration rate estimation in those who are transgender, 3 categories of transitioning: social, medical, & surgical - and that there is no singular transition path for transgender people. Our guests and the Nephrons also share their bracket picks for this region. Which team is your pick? Submit your brackets and try to match the Blue Ribbon Panel's bracket at nephmadness.com by the end of March 2023.

Nephrons: Elinor Mannon, Sam Kant, Matthew Sparks, Samira Farouk

Guests: Mitchell Lunn, Sehrish Ali

Links from the Show:

02:13 Growing awareness for gender-affirming care

03:15 Lack of evidence based guideline on assessing estimated glomerular filtration rate (eGFR) in patients receiving gender affirming hormonal therapy (GAHT)

05:12 Effect of GAHT on kidney function

06:42 Creating a welcoming environment for the patient

09:17 Addressing patients with the correct pronoun

11:50 Health surveys offering limited assessment of gender identity

16:57 Lack of post graduate medical training in addressing disparities in LGBTQ+ community 

22:50 Acute kidney injury and chronic kidney disease in transgender individuals on GAHT

25:54 The effect of gender affirming medical interventions on improving mental health 

26:27 Gender affirming surgery

On Episode 8, guests Dr. L Parker Gregg and patient advocate Nichole Jefferson join us for a conversation about the importance of mental health in patients with kidney disease. Nichole shares with us the importance of attention to mental health and her journey from hemodialysis to peritoneal dialysis to 2 kidney transplants. We also discuss recent and upcoming research in this area. 

Links from the Show:

04:05:  Rates of depression among patients with kidney disease

06:10:  National estimates of mental health needs among adults with chronic kidney disease

06:41: The overlap of uremia and depression

09:28: The transition from dialysis to transplant

13:48: The CAST trial: effect of sertraline in patients with chronic kidney disease

14:42: The ASCEND trial: cognitive behavioral therapy vs sertraline in patients on hemodialysis

17:46: Adverse effects associated with antidepressant use in patients with chronic kidney disease

21:16: Resources for support for patients with kidney disease

23:06 CONCORD study: Combination of Novel Therapies for CKD Comorbid Depression

On Episode 7, guests Dr. Crystal Tyson and Dr. Annabel Biruete dive deep on diet and kidney health: why it matters for patients with kidney disease, how patients can be empowered to make dietary choices that may promote kidney health, and..what's the PLADO diet?

Nephrons: Elinor Mannon, Sam Kant, Matthew Sparks, Samira Farouk

Guests: Crystal Tyson, Annabel Biruete

Show notes coming soon!