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John C. Calhoun is among the most notorious and enigmatic figures in American political history. First elected to Congress in 1810, Calhoun went on to serve as secretary of war and vice president. But he is perhaps most known for arguing in favor of slavery as a "positive good" and for his famous doctrine of "state interposition", which laid the groundwork for the South to secede from the Union - and arguably set the nation on course for civil war. The strain of radical politics he developed has found expression once again in the tactics and extremism of the modern Far Right.

On the outskirts of Buenos Aires in 1907, Doctor Quintana pines for head nurse Menéndez while he and his colleagues embark on a grisly series of experiments to investigate the line between life and death. One hundred years later, a celebrated artist goes to extremes in search of aesthetic transformation, turning himself into an art object. How far are we willing to go, Larraquy asks, in pursuit of transcendence?